phenyl 4-chlorobenzenesulfonate

Base Information

• Chemical Name: phenyl 4-chlorobenzenesulfonate
• CAS No.: 2437-33-4
• Molecular Formula: C12H9 Cl O3 S
• Molecular Weight: 268.721
• Mol file: 2437-33-4.mol

Synonyms:Benzenesulfonicacid, p-chloro-, phenyl ester (6CI,7CI); NSC 1868; Phenyl4-chlorophenylsulfonate; Phenyl p-chlorobenzenesulfonate

Chemical Property of phenyl 4-chlorobenzenesulfonate

Chemical Property:

• Vapor Pressure: 3.04E-06mmHg at 25°C
• Boiling Point: 400°Cat760mmHg
• Flash Point: 195.7°C
• Density: 1.377g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of phenyl 4-chlorobenzenesulfonate

There total 11 articles about phenyl 4-chlorobenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

sodium p-chlorobenzenesulphinate (14752-66-0) + phenol (108-95-2,27073-41-2) → 4-chlorobenzolsulfonsaeure-phenylester (2437-33-4)

Guidance literature:

In water; acetonitrile; at 20 ℃; for 2h; Electrochemical reaction;

DOI:10.1021/acs.joc.1c00260

Reference yield: 90.0%

carbamic acid phenyl ester (622-46-8) + 4-chlorobenzenesulfonyl chloride (98-60-2) → 4-Chlorobenzenesulfonamide (98-64-6) + 4-chlorobenzolsulfonsaeure-phenylester (2437-33-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 45 ℃; for 16h;

DOI:10.1016/j.tetlet.2003.10.139

Reference yield: 89.0%

10-phenylphenothiabismine 5,5-dioxide + 4-chloro-benzenesulfonic acid (98-66-8) → 4-chlorobenzolsulfonsaeure-phenylester (2437-33-4)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 4h; Heating;

DOI:10.3987/com-07-s(w)63

upstream raw materials:

sodium phenoxide

4-chlorobenzenesulfonyl chloride

phenol

carbamic acid phenyl ester

Downstream raw materials:

N-(4-methylbenzyl)aniline

4-chloro-benzenesulfonic acid

4-chloro-N-(4-methylbenzyl)benzenesulfonamide

phenol

Refernces

• 1、 Perez, Kaitlyn A.,Rogers, Cameron R.,Weiss, Emily A.. "Quantum Dot-Catalyzed Photoreductive Removal of Sulfonyl-Based Protecting Groups". supporting information. p. 14091 - 14095. Retrieved 2020/06/08.
• 2、 Dauvergne, Jér?me,Wellington, Kevin,Chibale, Kelly. "Unprecedented observation of sulfonamides in the transesterification of N-unsubstituted carbamates with sulfonyl chlorides". . p. 43 - 47. Retrieved 2007/10/03.