3-(4-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER

Base Information

• Chemical Name: 3-(4-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER
• CAS No.: 22767-72-2
• Molecular Formula: C12H16 O3
• Molecular Weight: 208.257
• Hs Code.: 2918990090
• Mol file: 22767-72-2.mol

Synonyms:Hydrocinnamicacid, p-methoxy-, ethyl ester (8CI); 3-(4-Methoxyphenyl)propanoic acid ethylester; Ethyl 3-(4-methoxyphenyl)propanoate; Ethyl3-(4-methoxyphenyl)propionate; Ethyl 3-(p-methoxyphenyl)propionate; Ethylp-methoxyhydrocinnamate; NSC 408331

Chemical Property of 3-(4-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0.00199mmHg at 25°C
• Refractive Index: 1.5016 (589.3 nm 25℃)
• Boiling Point: 291.1°Cat760mmHg
• Flash Point: 117.7°C
• PSA: 35.53000
• Density: 1.045g/cm³
• LogP: 2.19090
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 3-(4-methoxyphenyl)propanoate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER

There total 47 articles about 3-(4-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl p-methoxycinnamate (24393-56-4,51507-22-3,1929-30-2) → ethyl 3-(4-methoxyphenyl)propanoate (22767-72-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 10 - 35 ℃; for 6h;

Reference yield: 100.0%

3-(4-methoxyphenyl)propanoic acid (1929-29-9) + Diethyl carbonate (105-58-8,76619-83-5) → ethyl 3-(4-methoxyphenyl)propanoate (22767-72-2)

Guidance literature:

With Novozym 435; acylase I from Aspergillus melleus; amano lipase AK from pseudomonas fluorescens; lipase from wheat germ; papaine; In toluene; at 40 ℃; for 48h; Mechanism; Enzymatic reaction;

DOI:10.1016/j.molcatb.2014.02.020

Reference yield: 99.0%

ethyl (E)-3-(4-methoxyphenyl)prop-2-enoate (24393-56-4) → ethyl 3-(4-methoxyphenyl)propanoate (22767-72-2)

Guidance literature:

With 0.42C₂₃H₂₀N₄O₄*2Cl^(1-)*Zn⁽²⁺⁾*10.16H₂O*0.58Pd⁽²⁺⁾*0.58C₂₃H₂₀N₄O₄^(1-); hydrogen; In tetrahydrofuran; at 20 ℃; for 1h; under 760.051 Torr;

DOI:10.1021/ja309158a

upstream raw materials:

ethanol

3-(4-methoxyphenyl)propanoic acid

ethyl (E)-3-(4-methoxyphenyl)prop-2-enoate

ethyl p-methoxycinnamate

Downstream raw materials:

3-(p-methoxyphenyl)-1-propanol

4-hydroxyphenylpropionic acid

2-azido-3-(4-methoxy-phenyl)-propionic acid ethyl ester

ethyl 3-(3-hexanoyl-4-methoxyphenyl)propanoate

Refernces

• 1、 Devlin, Rory,Jones, David J.,Mcglacken, Gerard P.. "One-Pot, Tandem Wittig Hydrogenation: Formal C(sp3)-C(sp3) Bond Formation with Extensive Scope". supporting information. p. 5223 - 5228. Retrieved 2020/07/14.
• 2、 Mendes-Burak, Jorge,Ghaffari, Behnaz,Copéret, Christophe. "Selective hydrogenation of α,β-unsaturated carbonyl compounds on silica-supported copper nanoparticles". supporting information. p. 179 - 181. Retrieved 2019/01/04.