Guanosine, N-benzoyl-6-O-[2-(4-nitrophenyl)ethyl]-, 2',3',5'-tribenzoate

Base Information

• Chemical Name: Guanosine, N-benzoyl-6-O-[2-(4-nitrophenyl)ethyl]-, 2',3',5'-tribenzoate
• CAS No.: 86137-69-1
• Molecular Formula: C46H36N6O11
• Molecular Weight: 848.825
• Mol file: 86137-69-1.mol

Synonyms:

Chemical Property of Guanosine, N-benzoyl-6-O-[2-(4-nitrophenyl)ethyl]-, 2',3',5'-tribenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Guanosine, N-benzoyl-6-O-[2-(4-nitrophenyl)ethyl]-, 2',3',5'-tribenzoate

There total 1 articles about Guanosine, N-benzoyl-6-O-[2-(4-nitrophenyl)ethyl]-, 2',3',5'-tribenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

N2,O2',O3',O5'-tetrabenzoylguanosine (28288-50-8) + 2-(4-nitrophenyl)ethanol (100-27-6) → N2,2',3',5'-tetrabenzoyl-O6-nitrophenylethylguanosine (86137-69-1)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; for 18h; Ambient temperature;

DOI:10.1016/0040-4020(84)85103-0

Reference yield: 87.0%

N2,2',3',5'-tetrabenzoyl-O6-nitrophenylethylguanosine (86137-69-1) → N2,O2',O3',O5'-tetrabenzoylguanosine (28288-50-8)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In pyridine; for 3h; Ambient temperature;

DOI:10.1016/0040-4020(84)85103-0

Reference yield: 57.0%

N2,2',3',5'-tetrabenzoyl-O6-nitrophenylethylguanosine (86137-69-1) → N2-benzoyl-O6-p-nitrophenylethylguanosine (86137-71-5)

Guidance literature:

With ammonia; In 1,4-dioxane; methanol; for 192h; Ambient temperature;

DOI:10.1016/0040-4020(84)85103-0

upstream raw materials:

N²,O^2',O^3',O^5'-tetrabenzoylguanosine

2-(4-nitrophenyl)ethanol

Downstream raw materials:

N²,O^2',O^3',O^5'-tetrabenzoylguanosine

N²-benzoyl-O⁶-p-nitrophenylethylguanosine

Refernces

• 1、 Himmelsbach, Frank,Schulz, Bernd S.,Trichtinger, Thomas,Charubala, Ramamurthy,Pfleiderer, Wolfgang. "THE p-NITROPHENYLETHYL (NPE) GROUP. A VERSATILE NEW BLOCKING GROUP FOR PHOSPHATE AND AGLYCONE PROTECTION IN NUCLEOSIDES AND NUCLEOTIDES". . p. 59 - 72. Retrieved 2007/10/02.