Quinazoline, 4-methyl- (6CI,7CI,8CI,9CI)

Base Information

• Chemical Name: Quinazoline, 4-methyl- (6CI,7CI,8CI,9CI)
• CAS No.: 700-46-9
• Molecular Formula: C9H8N2
• Molecular Weight: 144.176
• Hs Code.: 2933990090
• Mol file: 700-46-9.mol

Synonyms:4-Methyl-1,3-quinazoline;NSC 48974;

Chemical Property of Quinazoline, 4-methyl- (6CI,7CI,8CI,9CI)

Chemical Property:

• Vapor Pressure: 0.0192mmHg at 25°C
• Melting Point: 36-37 °C
• Refractive Index: 1.633
• Boiling Point: 261.049 °C at 760 mmHg
• PKA: 2.69±0.30(Predicted)
• Flash Point: 115.625 °C
• PSA: 25.78000
• Density: 1.142 g/cm³
• LogP: 1.93820
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

4-Methylquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Methylquinazoline is an abdominal sex pheromone in Jewel wasp and other animals.

Technology Process of Quinazoline, 4-methyl- (6CI,7CI,8CI,9CI)

There total 42 articles about Quinazoline, 4-methyl- (6CI,7CI,8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-(2-isocyanophenyl)ethan-1-one (521270-78-0) → 4-methylquinazoline (700-46-9)

Guidance literature:

With ammonium acetate; silver carbonate; In acetonitrile; at 25 ℃; for 4h;

DOI:10.1002/adsc.201701623

Reference yield: 92.0%

methanol (67-56-1) + 2-aminoacetophenone (551-93-9) → 4-methylquinazoline (700-46-9)

Guidance literature:

With tert.-butylhydroperoxide; copper(II) choride dihydrate; ammonium acetate; In water; at 60 ℃; for 6h;

DOI:10.1039/c9ob00392d

Reference yield: 88.0%

2-aminoacetophenone (551-93-9) + orthoformic acid triethyl ester (122-51-0) → 4-methylquinazoline (700-46-9)

Guidance literature:

With ammonium acetate; In neat (no solvent); at 110 ℃; for 1.5h; Green chemistry;

DOI:10.1002/jhet.2220

upstream raw materials:

4-methylquinazoline 3-oxide

ethanol

ethyl iodide

quinazolin-4-yl-acetic acid ethyl ester

Downstream raw materials:

4-(4-nitro-trans-styryl)-quinazoline

2-quinazolin-4-yl-1-(4-nitro-phenyl)-ethanol

(E)-4-(4-dimethylaminostyryl)quinazoline

4-methylquinazoline 3-oxide

Refernces

• 1、 Chen, Cheng-Yi,He, Fengxian,Tang, Guangrong,Yuan, Huiqing,Li, Ning,Wang, Jinmin,Faessler, Roger. "Synthesis of Quinazolines via an Iron-Catalyzed Oxidative Amination of N-H Ketimines". . p. 2395 - 2401. Retrieved 2018/02/23.
• 2、 Bhat, Subrahmanya Ishwar,Das,Trivedi, Darshak R.. "An Efficient Three-component, One-pot Synthesis of Quinazolines under Solvent-free and Catalyst-free Condition". . p. 1253 - 1259. Retrieved 2015/08/06.