Terfenadine

Base Information Edit

Chemical Name:Terfenadine
CAS No.:50679-08-8
Molecular Formula:C32H41NO2
Molecular Weight:471.683
Hs Code.:29333999
European Community (EC) Number:256-710-8
NSC Number:758627,665802
UNII:7BA5G9Y06Q
DSSTox Substance ID:DTXSID2023642
Nikkaji Number:J434.879F,J9.749G
Wikipedia:Terfenadine
Wikidata:Q417909
NCI Thesaurus Code:C29494
Pharos Ligand ID:MGQPMCMHRN4T
Metabolomics Workbench ID:42719
ChEMBL ID:CHEMBL17157
Mol file:50679-08-8.mol

Synonyms:alpha-(4-(1,1-Dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperdinebutanol;Balkis Saft Spezial;Cyater;Hisfedin;Rapidal;RMI 9918;RMI-9918;RMI9918;Seldane;Teldane;Terfedura;Terfemundin;Terfenadin AL;Terfenadin Heumann;Terfenadin Ratiopharm;Terfenadin Stada;terfenadin von ct;Terfenadin-ratiopharm;Terfenadine;Terfenidine;Ternadin;Triludan

Suppliers and Price of Terfenadine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Terfenadine
50mg
$ 65.00

Tocris
Terfenadine ≥98%(HPLC)
50
$ 63.00

Sigma-Aldrich
Terfenadine British Pharmacopoeia (BP) Reference Standard
$ 212.00

Sigma-Aldrich
Terfenadine British Pharmacopoeia (BP) Reference Standard
bp650
$ 212.00

Sigma-Aldrich
Terfenadine European Pharmacopoeia (EP) Reference Standard
$ 190.00

Sigma-Aldrich
Terfenadine European Pharmacopoeia (EP) Reference Standard
t0071000
$ 190.00

Sigma-Aldrich
Terfenadine
5g
$ 92.10

Sigma-Aldrich
Terfenadine
25g
$ 367.00

Sigma-Aldrich
Terfenadine United States Pharmacopeia (USP) Reference Standard
200mg
$ 348.00

Medical Isotopes, Inc.
Terfenadine
2.5 g
$ 625.00

Total 60 raw suppliers

Chemical Property of Terfenadine Edit

Chemical Property:

Appearance/Colour:white solid
Vapor Pressure:1.41E-16mmHg at 25°C
Melting Point:145-152 °C
Refractive Index:1.6310 (estimate)
Boiling Point:626.8 °C at 760 mmHg
PKA:pKa 9.21(H2O t = 25 I = 0.025) (Uncertain)
Flash Point:306.9 °C
PSA：43.70000
Density:1.088 g/cm³
LogP:6.38370
Storage Temp.:2-8°C
Solubility.:chloroform: soluble250 mg plus 5 ml of solvent, clear to very sl
Water Solubility.:0.001 g/100 mL (30 ºC)
XLogP3:6.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:9
Exact Mass:471.313729551
Heavy Atom Count:35
Complexity:582

Purity/Quality:

99% ^*data from raw suppliers

Terfenadine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(C)(C)C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O
Uses Nonsedating-type histamine H1-receptor antagonist. Antihistaminic H1 antihistamine It is used for relieving symptoms associated with seasonal allergic rhinitis and conjunctivitis, for angioneurotic edema and allergic skin reaction, and also as an ingredient of complex therapy for bronchial asthma. Synonyms of this drug are seldane, hystadin, trexil, and others. Terfenadine has been used to study the role of histamine in itch related to proteinase-activated receptors (PARs) in mice. Terfenadine has also been used to block histamine receptor type 1 to study the pathogenesis of 2,4-dinitrobenzene sulfonic acid (DNBS)-induced ulcerative colitis in rats.
Therapeutic Function Antihistaminic, Bronchodilator

Technology Process of Terfenadine

There total 9 articles about Terfenadine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%