3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

Base Information

• Chemical Name: 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
• CAS No.: 280744-09-4
• Molecular Formula: C19H12Cl2N2O2
• Molecular Weight: 371.22
• Hs Code.: 29339900
• European Community (EC) Number: 636-668-0
• DSSTox Substance ID: DTXSID90182349
• Nikkaji Number: J1.614.434G
• Wikidata: Q27088702
• Pharos Ligand ID: NWCZ86DPDZUS
• ChEMBL ID: CHEMBL102714
• Mol file: 280744-09-4.mol

Synonyms:3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;SB 216763;SB-216763;SB216763

Chemical Property of 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

Chemical Property:

• Vapor Pressure: 2.88E-14mmHg at 25°C
• Melting Point: 287-288.6 °C(lit.)
• Refractive Index: 1.701
• Boiling Point: 598.092 °C at 760 mmHg
• PKA: 7.27±0.60(Predicted)
• Flash Point: 315.515 °C
• PSA: 51.10000
• Density: 1.472 g/cm³
• LogP: 4.38110
• Storage Temp.: −20°C
• Solubility.: DMSO: 20 mg/mL, soluble
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 370.0275830
• Heavy Atom Count: 25
• Complexity: 621

Purity/Quality:

99% ^*data from raw suppliers

SB 216763 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C(C=C(C=C4)Cl)Cl
• Description: SB-216763 (280744-09-4) is a potent and selective inhibitor of glycogen synthase kinase-1 (GSK-3) IC50=34.3 nM.1 Acts at the ATP-binding domain. Displays protective effects in lung fibrosis mouse model.2 Displays neuroprotective effects on cultured neurons.3 SB-216763 maintains mouse embryonic stem cells in a pluripotent state.4?Cell permeable.
• Uses: SB 216763 is a potent and selective cell permeale ATP-competitive inhibitor of GSK3a. It stimulates glycogen synthesis in Chang human liver cells. SB-216763 was used to inhibit GSK-3β in human brain microvascular endothelial cell line and colorectal cancer cells.