2-chloro-6,7-dihydro-5H-Pyrrolo[1,2-a]iMidazole

Base Information

• Chemical Name: 2-chloro-6,7-dihydro-5H-Pyrrolo[1,2-a]iMidazole
• CAS No.: 91417-91-3
• Molecular Formula: C6H7ClN2
• Molecular Weight: 142.58600
• Mol file: 91417-91-3.mol

Synonyms:2-Chloro-5H,6,7-dihydropyrrolo[1,2-a]imidazole;2-Chloro-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole;

Chemical Property of 2-chloro-6,7-dihydro-5H-Pyrrolo[1,2-a]iMidazole

Chemical Property:

• Melting Point: 73 - 76 °C (diethyl ether)
• PSA: 17.82000
• LogP: 1.48270

Purity/Quality:

98% ^*data from raw suppliers

2-Chloro-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Chloro-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole is used in the preparation of triazinone compounds as T-type calcium channel inhibitors

Technology Process of 2-chloro-6,7-dihydro-5H-Pyrrolo[1,2-a]iMidazole

There total 2 articles about 2-chloro-6,7-dihydro-5H-Pyrrolo[1,2-a]iMidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-oxo-1-pyrrolidine acetamide (7491-74-9) → 2-Chloro-5H,6,7-dihydropyrrolo<1,2-a>imidazole (91417-91-3)

Guidance literature:

With trichlorophosphate; at 60 ℃; for 3h;

DOI:10.1007/BF00758995

Reference yield: 82.0%

2-(pyrrolidin-1-yl)acetamide (1804-94-0) → 2-Chloro-5H,6,7-dihydropyrrolo<1,2-a>imidazole (91417-91-3)

Guidance literature:

With trichlorophosphate; at 60 - 90 ℃;

DOI:10.1134/S107042801806012X

Reference yield: 94.0%

(p-hydroxyphenyl)boronic acid (71597-85-8) + 2-Chloro-5H,6,7-dihydropyrrolo<1,2-a>imidazole (91417-91-3) → 4-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)phenol

Guidance literature:

With C₂₄H₅₄P₂Pd; caesium carbonate; In 1,4-dioxane; at 90 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.8b00375

upstream raw materials:

2-oxo-1-pyrrolidine acetamide

2-(pyrrolidin-1-yl)acetamide

Downstream raw materials:

2-phenyl-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole

Refernces

• 1、 Kavina,Sizov,Yakovlev. "Fused Imidazoles: I. Synthesis of 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole Derivatives". . p. 901 - 911. Retrieved 2018/07/31.