2-Propenal, 3-(4-methoxyphenyl)-

Base Information

• Chemical Name: 2-Propenal, 3-(4-methoxyphenyl)-
• CAS No.: 1963-36-6
• Molecular Formula: C10H10O2
• Molecular Weight: 162.188
• Hs Code.: 2912499000
• DSSTox Substance ID: DTXSID60859692
• Wikidata: Q104667391
• Mol file: 1963-36-6.mol

Synonyms:3-(4-methoxyphenyl)prop-2-enal;2-Propenal, 3-(4-methoxyphenyl)-;p-MeO-cinnamaldehyde;4-methoxy cinnamaldehyde;para-methoxycinnamaldehyde;DTXSID60859692;AKOS028108636;AM85651;para-METHOXY CINNAMIC ALDEHYDE (PMCA);FT-0618935

Chemical Property of 2-Propenal, 3-(4-methoxyphenyl)-

Chemical Property:

• Vapor Pressure: 0.00067mmHg at 25°C
• Melting Point: 55-60 °C(lit.)
• Refractive Index: 1.559
• Boiling Point: 308.7 °C at 760 mmHg
• Flash Point: 146.5 °C
• PSA: 26.30000
• Density: 1.068 g/cm³
• LogP: 1.90730
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 162.068079557
• Heavy Atom Count: 12
• Complexity: 155

Purity/Quality:

98% ^*data from raw suppliers

3-(4-Methoxyphenyl)acrylaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C=CC=O

Technology Process of 2-Propenal, 3-(4-methoxyphenyl)-

There total 193 articles about 2-Propenal, 3-(4-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

Estragole (140-67-0) → 4-methoxy-trans-cinnamaldehyde (24680-50-0,71277-11-7,1963-36-6)

Guidance literature:

With water; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium dichloride; In 1,2-dichloro-ethane; at 50 ℃; for 2h; stereoselective reaction;

DOI:10.1021/ol1030316

Reference yield: 91.0%

(E)-p-methoxy-cinnamyl alcohol (53484-50-7) → 4-methoxy-trans-cinnamaldehyde (24680-50-0,71277-11-7,1963-36-6)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c00901

Reference yield: 86.0%

3-(4-methoxyphenyl)propional (20401-88-1) → 4-methoxy-trans-cinnamaldehyde (24680-50-0,71277-11-7,1963-36-6)

Guidance literature:

With manganese(IV) oxide; benzyl-methyl-amine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; at 20 ℃; for 6h;

DOI:10.1002/adsc.201300919

upstream raw materials:

4-methoxy-benzaldehyde

acetaldehyde

p-methoxycinnamyl alcohol

1,1,3-Triaethoxy-3-(p-methoxyphenyl)-propan

Downstream raw materials:

4-(4-methoxyphenyl)-1,1-dicyano-1,3-butadiene

(2-Chloro-phenyl)-[(E)-3-(4-methoxy-phenyl)-prop-2-en-(E)-ylidene]-amine

1-(4-methoxy-phenyl)-4-methyl-penta-1,4-dien-3-ol

iron pentacarbonyl

Refernces

• 1、 Barik, B. R.,Kundu, A. B.,Dey, A. K.. "TWO PHENOLIC CONSTITUENTS FROM ALPINIA GALANGA RHIZOMES". . p. 2126 - 2127. Retrieved 1987.
• 2、 ?otolová, Martina,Kamlar, Martin,Reme?, Marek,Géant, Pierre-Yves,Císa?ová, Ivana,?tícha, Martin,Vesely, Jan. "Enantioselective Organocatalytic Synthesis of 1,2,3-Trisubstituted Cyclopentanes". . p. 5080 - 5089. Retrieved 2021/09/30.
• 3、 Guo, Ying,Wang, Wei David,Li, Shengyu,Zhu, Yin,Wang, Xiaoyu,Liu, Xiao,Zhang, Yuan. "A TEMPO-Functionalized Ordered Mesoporous Polymer as a Highly Active and Reusable Organocatalyst". supporting information. p. 3689 - 3694. Retrieved 2021/09/29.