5-BROMO-2-(TRIFLUOROMETHOXY)BENZALDEHYDE

Base Information

• Chemical Name: 5-BROMO-2-(TRIFLUOROMETHOXY)BENZALDEHYDE
• CAS No.: 923281-52-1
• Molecular Formula: C8H4BrF3O2
• Molecular Weight: 269.018
• Hs Code.: 2913000090
• Mol file: 923281-52-1.mol

Synonyms:4-Bromo-2-formyl-alpha,alpha,alpha-trifluoroanisole

Chemical Property of 5-BROMO-2-(TRIFLUOROMETHOXY)BENZALDEHYDE

Chemical Property:

• Vapor Pressure: 0.0292mmHg at 25°C
• Refractive Index: 1.518
• Boiling Point: 245.1 °C at 760 mmHg
• Flash Point: 102 °C
• PSA: 26.30000
• Density: 1.706 g/cm³
• LogP: 3.16020
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Air Sensitive
• Water Solubility.: Soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromo-2-(trifluoromethoxy)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Bromo-2-(trifluoromethoxy)benzaldehyde is used in the synthesis of (-)-epicatechin, synthesis of biologically active compounds in vitro.

Technology Process of 5-BROMO-2-(TRIFLUOROMETHOXY)BENZALDEHYDE

There total 1 articles about 5-BROMO-2-(TRIFLUOROMETHOXY)BENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-morpholinecarboxaldehyde (4394-85-8) + 1-bromo-4-(trifluoromethoxy)benzene (407-14-7) → 5-bromo-2-(trifluoromethoxy)benzaldehyde (923281-52-1)

Guidance literature:

1-bromo-4-(trifluoromethoxy)benzene; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 2h;

4-morpholinecarboxaldehyde; In tetrahydrofuran; hexane;

Reference yield: 86.0%

5-bromo-2-(trifluoromethoxy)benzaldehyde (923281-52-1) → 5-bromo-2-(trifluoromethoxy)benzonitrile (1210906-15-2)

Guidance literature:

With hydroxylamine hydrochloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In ethyl acetate; N,N-dimethyl-formamide; at 100 ℃; for 8h;

Reference yield: 51.0%

5-bromo-2-(trifluoromethoxy)benzaldehyde (923281-52-1) + bis(pinacol)diborane (73183-34-3) → 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethoxy)benzaldehyde (923281-74-7)

Guidance literature:

With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 90 ℃; for 16h;

upstream raw materials:

4-morpholinecarboxaldehyde

1-bromo-4-(trifluoromethoxy)benzene

Downstream raw materials:

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethoxy)benzaldehyde

4-[1-(5-bromo-2-trifluoromethoxyphenyl)-methylidene]-2,2,5,5-tetramethyldihydrofuran-3-one

2-(5-bromo-2-trifluoromethoxyphenyl)cyclopentane-1,3-dione

5-(methoxymethyl)-2-(trifluoromethoxy)benzaldehyde

Refernces