Cyclohexanecarboxylic acid, 4-[[[(2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-7-yl)sulfonyl]amino]meth yl]-

Base Information

• Chemical Name: Cyclohexanecarboxylic acid, 4-[[[(2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-7-yl)sulfonyl]amino]meth yl]-
• CAS No.: 927869-66-7
• Molecular Formula: C18H24N2O5S
• Molecular Weight: 380.465
• Mol file: 927869-66-7.mol

Synonyms:

Chemical Property of Cyclohexanecarboxylic acid, 4-[[[(2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-7-yl)sulfonyl]amino]meth yl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclohexanecarboxylic acid, 4-[[[(2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-7-yl)sulfonyl]amino]meth yl]-

There total 6 articles about Cyclohexanecarboxylic acid, 4-[[[(2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-7-yl)sulfonyl]amino]meth yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

methyl 4-((2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-7-sulfonamido)methyl)cyclohexane carboxylate → 4-((2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-7-sulfonamido)methyl)cyclohexanecarboxylic acid (927869-66-7)

Guidance literature:

With water; potassium hydroxide; In methanol; at 60 ℃; for 4h;

Reference yield:

2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one (4424-80-0) → 4-((2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-7-sulfonamido)methyl)cyclohexanecarboxylic acid (927869-66-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / chlorosulfonic acid / CCl₄ / 3 h / 70 °C

2: aq. NaOH / 1 h / 60 °C

With chlorosulfonic acid; sodium hydroxide; In tetrachloromethane;

DOI:10.1080/00397910600943493

Reference yield:

3,4-dihydronaphthalene-1(2H)-one (529-34-0) → 4-((2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-7-sulfonamido)methyl)cyclohexanecarboxylic acid (927869-66-7)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium azide; sulfuric acid / toluene / 48 h / 0 - 20 °C

2: chlorosulfonic acid / 20 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 6 h / 20 °C

4: water; potassium hydroxide / methanol / 4 h / 60 °C

With chlorosulfonic acid; sodium azide; sulfuric acid; water; triethylamine; potassium hydroxide; In methanol; dichloromethane; toluene;

upstream raw materials:

2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-7-sulfonyl chloride

4-aminomethyl-cyclohexanecarboxylic acid

2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one

3,4-dihydronaphthalene-1(2H)-one

Refernces

• 1、 -. "XANTHINE DERIVATIVES AND USES THEREOF AS INHIBITORS OF BROMODOMAINS OF BET PROTEINS". . . Retrieved 2019/05/22.