Technology Process of 4-Pentynoic acid, 5-(5-chloro-2-nitrophenyl)-, methyl ester
There total 1 articles about 4-Pentynoic acid, 5-(5-chloro-2-nitrophenyl)-, methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0);
In
N,N-dimethyl-formamide;
at 20 ℃;
for 24h;
- Guidance literature:
-
methyl 5-(5-chloro-2-nitrophenyl)pent-4-ynoate;
With
tin(ll) chloride;
In
ethyl acetate;
at 20 ℃;
for 24h;
With
sodium hydroxide; water;
In
ethyl acetate;
at 0 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tin(ll) chloride; ethanol / ethyl acetate / 24 h / 20 °C
2: pyridine / 1 h / 20 °C
3: copper diacetate / 1,2-dichloro-ethane / 24 h / Reflux
4: lithium hydroxide monohydrate / water; tetrahydrofuran / 3 h / 20 °C
With
pyridine; lithium hydroxide monohydrate; ethanol; copper diacetate; tin(ll) chloride;
In
tetrahydrofuran; water; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1021/acs.jmedchem.7b01285
