Hydrastine

Base Information Edit

Chemical Name:Hydrastine
CAS No.:118-08-1
Deprecated CAS:28638-96-2,5988-13-6,26294-47-3,26294-47-3,5988-13-6
Molecular Formula:C21H21 N O6
Molecular Weight:383.401
Hs Code.:2939800000
European Community (EC) Number:204-233-0
NSC Number:757430
UNII:8890V3217X
DSSTox Substance ID:DTXSID9025409
Nikkaji Number:J9.349A
Wikipedia:Hydrastine
Wikidata:Q76084819
NCI Thesaurus Code:C76031
Metabolomics Workbench ID:123043
ChEMBL ID:CHEMBL1256919
Mol file:118-08-1.mol

Synonyms:beta-hydrastine;hydrastine;hydrastine hydrochloride, (S-(R*,S*))-isomer;hydrastine, (R-(R*,R*))-isomer;hydrastine, (R-(R*,S*))-isomer;isocoryne

Suppliers and Price of Hydrastine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(-)-β-Hydrastine
50mg
$ 1175.00

Sigma-Aldrich
(1R,9S)-(?)-β-Hydrastine United States Pharmacopeia (USP) Reference Standard
10mg
$ 536.00

DC Chemicals
Hydrastine >98%
10 mg
$ 88.00

Crysdot
Hydrastine 98+%
10mg
$ 76.00

Crysdot
Hydrastine 98+%
5mg
$ 55.00

Cayman Chemical
(1R,9S)-(–)-β-Hydrastine ≥98%
25mg
$ 193.00

Cayman Chemical
(1R,9S)-(–)-β-Hydrastine ≥98%
10mg
$ 105.00

Cayman Chemical
(1R,9S)-(–)-β-Hydrastine ≥98%
5mg
$ 55.00

Cayman Chemical
(1R,9S)-(–)-β-Hydrastine ≥98%
50mg
$ 330.00

Biorbyt Ltd
Hydrastine
10 mg
$ 248.20

Total 31 raw suppliers

Chemical Property of Hydrastine Edit

Chemical Property:

Vapor Pressure:4.28E-12mmHg at 25°C
Melting Point:132℃
Refractive Index:1.5614 (estimate)
Boiling Point:548.8°Cat760mmHg
PKA:7.8(at 25℃)
Flash Point:285.7°C
PSA：66.46000
Density:1.339g/cm³
LogP:2.81110
Storage Temp.:−20°C
Water Solubility.:30mg/L(20 oC)
XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:383.13688739
Heavy Atom Count:28
Complexity:601

Purity/Quality:

98%,99%, ^*data from raw suppliers

(-)-β-Hydrastine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 20/21/22
Safety Statements: 36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCC2=CC3=C(C=C2C1C4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)OCO3
Isomeric SMILES:CN1CCC2=CC3=C(C=C2[C@@H]1[C@@H]4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)OCO3
Description (1R,9S)-(–)-β-Hydrastine is an enantiomer of the alkaloid hydrastine that inhibits dopamine biosynthesis (IC50 = 20.7 μM in PC12 cells) by inhibiting tyrosine hydroxylase activity. It inhibits dopamine release with an IC50 value of 66.5 μM in the presence of high extracellular K+ levels. It also inhibits L-type and caffeine-activated store-operated Ca2+ channels and prevents Ca2+ leakage from intracellular stores.
Uses (-)-β-Hydrastine is an inhibitor of Dopamine biosynthesis. Inhibitor of Dopamine biosynthesis. anesthetic (local), antiarrhythmic

Technology Process of Hydrastine

There total 34 articles about Hydrastine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%