4-Methoxybutan-1-ol

Base Information

• Chemical Name: 4-Methoxybutan-1-ol
• CAS No.: 111-32-0
• Molecular Formula: C5H12O2
• Molecular Weight: 104.149
• Hs Code.: 29094990
• European Community (EC) Number: 203-858-6
• NSC Number: 245191
• UNII: AH4W8HA8JH
• DSSTox Substance ID: DTXSID50149438
• Nikkaji Number: J49.693F
• Wikidata: Q72489401
• Mol file: 111-32-0.mol

Synonyms:4-Methoxybutan-1-ol;111-32-0;4-METHOXY-1-BUTANOL;1-Butanol, 4-methoxy-;Dowanol BMAT;Dowanol bm;Butylene glycol methyl ether;4-Methoxybutyl alcohol;1,4-Butanediol Monomethyl Ether;4-Methoxybutanol;Dowanal BMAT;Butylene glycol monomethyl ether;NSC 245191;EINECS 203-858-6;AH4W8HA8JH;BRN 1732309;Tetramethylene Glycol Monomethyl Ether;NSC-245191;4-Methoxybutanol-1;4-methoxy-butan-1-ol;C(CCO)COC;UNII-AH4W8HA8JH;SCHEMBL23986;WLN: Q4O1;DTXSID50149438;BUTAN-1-OL, 4-METHOXY-;BCP23225;BBL100500;MFCD00040437;NSC245191;STL554294;AKOS005254381;LS-46562;MS-20025;AM20080057;B2402;CS-0150179;FT-0656133;EN300-42852;D78159;Q-103486;Z431605254

Chemical Property of 4-Methoxybutan-1-ol

Chemical Property:

• Vapor Pressure: 0.618mmHg at 25°C
• Refractive Index: 1.41
• Boiling Point: 165.7 °C at 760 mmHg
• PKA: 15.08±0.10(Predicted)
• Flash Point: 54.1 °C
• PSA: 29.46000
• Density: 0.906 g/cm³
• LogP: 0.40530
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Slightly soluble in water.
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 104.083729621
• Heavy Atom Count: 7
• Complexity: 29.3

Purity/Quality:

99% ^*data from raw suppliers

4-Methoxy-1-butanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F
• Hazard Codes: F
• Statements: 36/37/38-10
• Safety Statements: 26-36/37/39-35-3/9/49-15

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCCCO
• Uses: 4-Methoxy-1-butanol is used as a chemicals, pharmaceutical intermediates, reagents. 4-Methoxy-1-butanol is used with n-butyl acetate to improve dissolving power, drying time, and flow.

Technology Process of 4-Methoxybutan-1-ol

There total 17 articles about 4-Methoxybutan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

O-methyltetrahydrofuranium perchlorate → tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + methanol (67-56-1) + 4-methoxybutanol (111-32-0)

Guidance literature:

With perchloric acid; sodium perchlorate; water; at 25 ℃;

DOI:10.1021/ja00544a025

Reference yield: 90.0%

1,3-dioxepane (505-65-7) → 4-methoxybutanol (111-32-0)

Guidance literature:

With diisobutylaluminium hydride; In benzene; for 2h; Heating;

Reference yield: 88.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) → methanol (67-56-1) + 4-methoxybutanol (111-32-0)

Guidance literature:

With perchloric acid; sodium perchlorate; water; In tetrahydrofuran; at 25 ℃; Product distribution; Kinetics; Rate constant; pH 4.0; reaction with different pH;

DOI:10.1021/ja00544a025

upstream raw materials:

cis,trans-2,5-dimethoxytetrahydrofuran

2-nitroso-3,6-dihydro-2H-[1,2]oxazine

3-bromo-2-methoxy-tetrahydrofuran

Butane-1,4-diol

Downstream raw materials:

4-Methoxy-butyl-trimethylsilylaether

4-methoxybutyl 4-methyl-benzenesulfonate

4-methoxybutyric acid

Refernces

• 1、 Blandamer et al.. "". . p. 2678,2679. Retrieved 1969.
• 2、 Nishikawa, Sadakatsu,Matsumura, Kenichi,Ueda, Masayuki. "Effect of Ether Oxygen in Isomeric Alcohols on Water Structure Estimated from Ultrasonic Absorption and Velocity Data". . p. 682 - 686. Retrieved 1993.
• 3、 Hu, Xun,Westerhof, Roel J. M.,Wu, Liping,Dong, Dehua,Li, Chun-Zhu. "Upgrading biomass-derived furans via acid-catalysis/hydrogenation: The remarkable difference between water and methanol as the solvent". . p. 219 - 224. Retrieved 2018/04/16.
• 4、 Chen, Xin,Brauman, John I.. "Hydrogen bonding lowers intrinsic nucleophilicity of solvated nucleophiles". scheme or table. p. 15038 - 15046. Retrieved 2009/03/12.