1-(2-(3-iodo-4-aminophenyl)ethyl)-4-(3-(trifluoromethyl)phenyl)piperazine

Base Information

• Chemical Name: 1-(2-(3-iodo-4-aminophenyl)ethyl)-4-(3-(trifluoromethyl)phenyl)piperazine
• CAS No.: 118249-07-3
• Molecular Formula: C19H21 F3 I N3
• Molecular Weight: 475.29
• Mol file: 118249-07-3.mol

Synonyms:1-(2-(3-iodo-4-aminophenyl)ethyl)-4-(3-(trifluoromethyl)phenyl)piperazine

Chemical Property of 1-(2-(3-iodo-4-aminophenyl)ethyl)-4-(3-(trifluoromethyl)phenyl)piperazine

Chemical Property:

• Vapor Pressure: 1.69E-10mmHg at 25°C
• Boiling Point: 509.5°Cat760mmHg
• Flash Point: 261.9°C
• PSA: 32.50000
• Density: 1.538g/cm³
• LogP: 4.84100

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-(3-iodo-4-aminophenyl)ethyl)-4-(3-(trifluoromethyl)phenyl)piperazine

There total 5 articles about 1-(2-(3-iodo-4-aminophenyl)ethyl)-4-(3-(trifluoromethyl)phenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.6%

1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine (1814-64-8) → 1-[2-(3-Iodo-4-aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine (118249-07-3)

Guidance literature:

With Iodine monochloride; In acetic acid; for 3.5h; Ambient temperature;

DOI:10.1021/jm00123a006

Reference yield:

4-nitrobenzeneacetic acid (104-03-0) → 1-[2-(3-Iodo-4-aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine (118249-07-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 1,3-dicyclohexylcarbodiimide / CHCl₃ / Ambient temperature

2: CHCl₃ / Ambient temperature

3: 89 percent / borane-THF / tetrahydrofuran / 24 h / Ambient temperature

4: 88.9 percent / SnCl₂, conc. HCl / aq. ethanol / 3 h / Heating

5: 62.6 percent / iodomonochloride / acetic acid / 3.5 h / Ambient temperature

With hydrogenchloride; borane-THF; Iodine monochloride; dicyclohexyl-carbodiimide; tin(ll) chloride; In tetrahydrofuran; ethanol; chloroform; acetic acid;

DOI:10.1021/jm00123a006

Reference yield:

1-<2-(4-Nitrophenyl)ethyl>-4-<3-(trifluoromethyl)phenyl>piperazine (2195-13-3) → 1-[2-(3-Iodo-4-aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine (118249-07-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 88.9 percent / SnCl₂, conc. HCl / aq. ethanol / 3 h / Heating

2: 62.6 percent / iodomonochloride / acetic acid / 3.5 h / Ambient temperature

With hydrogenchloride; Iodine monochloride; tin(ll) chloride; In ethanol; acetic acid;

DOI:10.1021/jm00123a006

upstream raw materials:

1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine

4-nitrobenzeneacetic acid

1-<2-(4-Nitrophenyl)ethyl>-4-<3-(trifluoromethyl)phenyl>piperazine

4-nitrophenylacetic acid O-(N-hydroxy)succinimide ester

Downstream raw materials:

1-[2-(3-Iodo-4-azidophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine

Refernces