2,4-Dichloro-5-fluoroquinazoline

Base Information

• Chemical Name: 2,4-Dichloro-5-fluoroquinazoline
• CAS No.: 87611-00-5
• Molecular Formula: C8H3Cl2FN2
• Molecular Weight: 217.03
• Hs Code.: 2933599590
• Mol file: 87611-00-5.mol

Synonyms:4-dichloro-5-fluoroquinazoline;2,4-DICHLORO-5-FLUOROQUINAZOLINE;Quinazoline, 2,4-dichloro-5-fluoro-

Chemical Property of 2,4-Dichloro-5-fluoroquinazoline

Chemical Property:

• Boiling Point: 277.3±22.0 °C(Predicted)
• PKA: -0.91±0.30(Predicted)
• PSA: 25.78000
• Density: 1.571±0.06 g/cm3(Predicted)
• LogP: 3.07570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Dichloro-5-fluoroquinazoline >97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Dichloro-5-fluoroquinazoline

There total 3 articles about 2,4-Dichloro-5-fluoroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.8%

5-fluoro-1H-quinazoline-2,4(1H,3H)-dione (192570-33-5) → 2,4-dichloro-5-fluoroquinazoline (87611-00-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; In toluene; at 50 - 120 ℃;

Reference yield:

2-amino-6-fluorobenzoic acid (434-76-4) → 2,4-dichloro-5-fluoroquinazoline (87611-00-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / water / 0.25 h / 35 °C

1.2: 0.5 h / 35 °C

2.1: trichlorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 50 - 120 °C

With acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; In water; toluene;

Reference yield:

→ 2,4-dichloro-5-fluoroquinazoline (87611-00-5)

Guidance literature:

upstream raw materials:

5-fluoro-1H-quinazoline-2,4(1H,3H)-dione

2-amino-6-fluorobenzoic acid

Downstream raw materials:

2-((2-chloro-5-fluoro-4-oxoquinazolin-3(4H)-yl)methyl)benzonitrile

Refernces

• 1、 -. "ADENOSINE A2A RECEPTOR ANTAGONISTS". Page/Page column 11. . Retrieved 2008/12/04.