Dihydro Fenofibrate

Base Information

• Chemical Name: Dihydro Fenofibrate
• CAS No.: 61001-99-8
• Molecular Formula: C20H23ClO4
• Molecular Weight: 362.853
• Mol file: 61001-99-8.mol

Synonyms:Dihydro Fenofibrate;

Chemical Property of Dihydro Fenofibrate

Chemical Property:

• PSA: 55.76000
• LogP: 4.53070
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

Dihydro Fenofibrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of Fenofibrate; a reduced analog of Fenofibrate.

Technology Process of Dihydro Fenofibrate

There total 5 articles about Dihydro Fenofibrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

fenofibrate (49562-28-9) → 4-((4-chlorophenyl)(hydroxy)methyl)phenol (61001-99-8)

Guidance literature:

With C₂₈H₃₅ClCoN₅⁽¹⁺⁾*Cl^(1-); potassium tert-butylate; hydrogen; In tetrahydrofuran; at 20 ℃; for 16h; under 37503.8 Torr; Pressure; Temperature; Autoclave;

DOI:10.1016/j.chempr.2019.03.010

Reference yield:

4-chloro-4'-hydroxybenzophenone (42019-78-3) → 4-((4-chlorophenyl)(hydroxy)methyl)phenol (61001-99-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide

2: sulfuric acid

3: potassium borohydride

With sodium hydroxide; potassium borohydride; sulfuric acid;

Reference yield:

fenofibric acid (42017-89-0) → 4-((4-chlorophenyl)(hydroxy)methyl)phenol (61001-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid

2: potassium borohydride

With potassium borohydride; sulfuric acid;

upstream raw materials:

fenofibrate

4-chloro-4'-hydroxybenzophenone

fenofibric acid

4-chloro-benzoyl chloride

Downstream raw materials:

fenofibrate

fenirofibrate

Refernces