3-Amino-4-methylpent-2-enoic acid methyl ester

Base Information

• Chemical Name: 3-Amino-4-methylpent-2-enoic acid methyl ester
• CAS No.: 124703-77-1
• Molecular Formula: C7H13NO2
• Molecular Weight: 143.186
• Hs Code.: 2922499990
• Mol file: 124703-77-1.mol

Synonyms:3-Amino-4-methylpent-2-enoic acid methyl ester;Methyl 3-amino-4-methyl-2-pentenoate

Chemical Property of 3-Amino-4-methylpent-2-enoic acid methyl ester

Chemical Property:

• Boiling Point: 223℃
• Flash Point: 91℃
• PSA: 52.32000
• Density: 0.987
• LogP: 1.35830
• Storage Temp.: 2-8°C

Purity/Quality:

≥98.746% ^*data from raw suppliers

Methyl3-amino-4-methylpent-2-enoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Amino-4-methylpent-2-enoic acid methyl ester

There total 2 articles about 3-Amino-4-methylpent-2-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

Methyl 4-methyl-3-oxopentanoate (42558-54-3) → methyl 3-amino-4-methylpent-2-enoate (124703-77-1)

Guidance literature:

With ammonium acetate; In methanol; at 55 ℃; for 5h; Inert atmosphere;

Reference yield:

3-methyl-butan-2-one (563-80-4) → methyl 3-amino-4-methylpent-2-enoate (124703-77-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / toluene / Inert atmosphere; Reflux

2: ammonium acetate / methanol / Reflux

With ammonium acetate; sodium hydride; In methanol; toluene;

DOI:10.1021/acs.orglett.0c00006

Reference yield: 72.0%

benzenediazonium tetrafluoroborate (369-57-3) + methyl 3-amino-4-methylpent-2-enoate (124703-77-1) → methyl 5-isopropyl-2-phenyl-2H-1,2,3-triazole-4-carboxylate

Guidance literature:

With caesium carbonate; copper dichloride; In acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1021/acs.orglett.0c00006

upstream raw materials:

Methyl 4-methyl-3-oxopentanoate

3-methyl-butan-2-one

Refernces

• 1、 Wu, Yan,Qi, Shan-Bin,Wu, Fei-Fei,Zhang, Xi-Chang,Li, Min,Wu, Jing,Chan, Albert S. C.. "Synthesis of β-amino acid derivatives via copper-catalyzed asymmetric 1,4-reduction of β-(acylamino)acrylates". . p. 1754 - 1757. Retrieved 2011.
• 2、 -. "NOVEL RUTHENIUM CATALYSTS AND THEIR USE FOR ASYMMETRIC REDUCTION OF KETONES". Page/Page column 24; 25. . Retrieved 2015/01/16.