Technology Process of Benzoic acid, 2-amino-3,4-difluoro-, methyl ester (9CI)
There total 5 articles about Benzoic acid, 2-amino-3,4-difluoro-, methyl ester (9CI) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 0 - 20 ℃;
for 16h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C
2.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / 20 - 80 °C / Inert atmosphere
2.2: 16 h / 80 °C / Inert atmosphere
3.1: sodium acetate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 16 h / 75 °C / Inert atmosphere
4.1: trifluoroacetic acid / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
With
2,2,6,6-tetramethyl-piperidine; n-butyllithium; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; diphenyl phosphoryl azide; sodium acetate; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; hexane; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / 20 - 80 °C / Inert atmosphere
1.2: 16 h / 80 °C / Inert atmosphere
2.1: sodium acetate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 16 h / 75 °C / Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
With
palladium bis[bis(diphenylphosphino)ferrocene] dichloride; diphenyl phosphoryl azide; sodium acetate; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane;