2-Ethylpyridine

Base Information

• Chemical Name: 2-Ethylpyridine
• CAS No.: 100-71-0
• Molecular Formula: C7H9N
• Molecular Weight: 107.155
• Hs Code.: 29333999
• European Community (EC) Number: 202-881-9
• NSC Number: 964
• UNII: 06X1W46PYX
• DSSTox Substance ID: DTXSID4021844
• Nikkaji Number: J4.013D
• Wikidata: Q27236227
• ChEMBL ID: CHEMBL279305
• Mol file: 100-71-0.mol

Synonyms:2-ethylpyridine

Chemical Property of 2-Ethylpyridine

Chemical Property:

• Appearance/Colour: clear colorless to yellowish liquid
• Vapor Pressure: 4.93mmHg at 25°C
• Melting Point: -63 °C
• Refractive Index: n20/D 1.496(lit.)
• Boiling Point: 150.3 °C at 760 mmHg
• PKA: 5.89(at 25℃)
• Flash Point: 29.4 °C
• PSA: 12.89000
• Density: 0.937 g/cm³
• LogP: 1.64400
• Storage Temp.: Flammables area
• Solubility.: 42g/l
• Water Solubility.: ca 45 g/L (20 ºC)
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 107.073499291
• Heavy Atom Count: 8
• Complexity: 61.4

Purity/Quality:

99% ^*data from raw suppliers

2-Ethylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Pyridines
• Canonical SMILES: CCC1=CC=CC=N1
• Uses: 2-Ethylpyridine is used to study its effect on the proliferation and survival of human umbilical vein endothelial cells (HUVECs), HMVECs from lung, and NIH 3T3 cells. 2-Ethylpyridine linked with silica is a popular stationary phase for chiral and achiral separations in supercritical fluid chromatography. 2-Ethylpyridine is used to study its effect on the proliferation and survival of human umbilical vein endothelial cells (HUVECs), HMVECs from lung, and NIH 3T3 cells.

Technology Process of 2-Ethylpyridine

There total 70 articles about 2-Ethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

pyridine (110-86-1) + diethylmagnesium (557-18-6) + ethyllithium (811-49-4) → 2-Ethylpyridine (100-71-0) + 4-Ethylpyridine (536-75-4,151103-55-8)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; In diethyl ether; benzene; at 25 ℃; for 22h;

DOI:10.1016/S0040-4039(01)80795-4

Reference yield: 22.2%

pyridine (110-86-1) + methanol (67-56-1) → 2-vinylpyridine (100-69-6,25014-15-7,27476-03-5,329041-71-6) + α-picoline (109-06-8) + picoline (108-89-4) + 2-Ethylpyridine (100-71-0) + 4-Ethylpyridine (536-75-4,151103-55-8) + 3-Methylpyridine (108-99-6)

Guidance literature:

Cs exchanged zeolite; at 450 ℃; Product distribution; investigation of the heterogeneous vapor-phase alkylation of pyridine with methanol over Na⁺, K⁺, Rb⁺, or Cs⁺ exchanged X- or Y-type zeolite in an atmosphere of nitrogen;

Reference yield: 15.0%

pyridine (110-86-1) + diethylmagnesium (557-18-6) → 2-Ethylpyridine (100-71-0) + 4-Ethylpyridine (536-75-4,151103-55-8)

Guidance literature:

With 15-crown-5; In tetrahydrofuran; at 40 ℃; for 72h; Product distribution; Mechanism; polyether dependence, various reaction times, different dialkylmagnesium compounds;

DOI:10.1021/ja00381a027

upstream raw materials:

pyridine

diethyl ether

ethanol

1,2-Diiodoethane

Downstream raw materials:

pyridine

ethylbenzene

6-(hydroxymethyl-ethyl)pyridine

2-ethyl-1-tetradecyl-pyridinium; bromide

Refernces

• 1、 Osuch,Levine. "-". . p. 1723. Retrieved 1956.
• 2、 Merz, Lukas S.,Blasius, Clemens K.,Wadepohl, Hubert,Gade, Lutz H.. "Square Planar Cobalt(II) Hydride versus T-Shaped Cobalt(I): Structural Characterization and Dihydrogen Activation with PNP-Cobalt Pincer Complexes". . p. 6102 - 6113. Retrieved 2019.
• 3、 Wei, Zeyuan,Wang, Yujie,Li, Yibiao,Ferraccioli, Raffaella,Liu, Qiang. "Bidentate NHC-Cobalt Catalysts for the Hydrogenation of Hindered Alkenes". . p. 3082 - 3087. Retrieved 2020.
• 4、 Schulz, W.,Pracejus, H.,Oehme, G.. "PHOTOASSISTED COCYCLIZATION OF ACETYLENE AND NITRILES CATALYZED BY COBALT COMPLEXES AT AMBIENT TEMPERATURE AND NORMAL PRESSURE". . p. 1229 - 1232. Retrieved 1989.
• 5、 Pagano, Justin K.,Stelmach, John P. W.,Waterman, Rory. "Cobalt-catalyzed ammonia borane dehydrocoupling and transfer hydrogenation under aerobic conditions". . p. 12074 - 12077. Retrieved 2015.
• 6、 Reinecke,Kray. "-". . p. 5355. Retrieved 1964.
• 7、 Smit, Christian,Fraaije, Marco W.,Minnaard, Adriaan J.. "Reduction of carbon-carbon double bonds using organocatalytically generated diimide". . p. 9482 - 9485. Retrieved 2008.
• 8、 Oae, Shigeru,Takeda, Takeshi,Uenishi, Junichi,Wakabayashi, Shoji. "Ligand coupling reactions of 2-pyridyl, 4-pyridyl and 2-pyrimidyl sulfoxides with grignard reagents". . p. 179 - 182. Retrieved 1996.
• 9、 Richey, Herman G.,Farkas, Julius. "REACTIONS OF DIETHYLMAGNESIUM - ETHYLLITHIUM SOLUTIONS WITH PYRIDINE". . p. 275 - 278. Retrieved 1985.
• 10、 Brown,Murphey. "-". . p. 3308,3310. Retrieved 1951.