1-(2-Hydroxyethyl)cyclobutanol

Base Information

• Chemical Name: 1-(2-Hydroxyethyl)cyclobutanol
• CAS No.: 83237-27-8
• Molecular Formula: C6H12O2
• Molecular Weight: 116.16
• Mol file: 83237-27-8.mol

Synonyms:1-(2-hydroxyethyl)cyclobutanol;1-(1-Hydroxy-cyclobutyl)-2-hydroxy-aethan;

Chemical Property of 1-(2-Hydroxyethyl)cyclobutanol

Chemical Property:

• Boiling Point: 102 °C(Press: 2 Torr)
• PKA: 14.90±0.20(Predicted)
• PSA: 40.46000
• Density: 1.049 g/cm3
• LogP: 0.28380

Purity/Quality:

99%min ^*data from raw suppliers

1-(2-Hydroxyethyl)cyclobutanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-Hydroxyethyl)cyclobutanol

There total 4 articles about 1-(2-Hydroxyethyl)cyclobutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 5,7-dioxaspiro<3.5>nonane (73637-29-3) → Dimethoxymethane (109-87-5) + 1-hydroxy-1-(β-hydroxyethyl)cyclobutane (83237-27-8) + 1-methoxy-1-(β-hydroxyethyl)cyclobutane (83237-26-7)

Guidance literature:

With sulfuric acid; Yield given. Yields of byproduct given; to reflux, further reagent;

DOI:10.1007/BF00954189

Reference yield:

1-oxa-spiro[2.3]hexane-2-carboxylic acid ethyl ester (73039-83-5) → 1-hydroxy-1-(β-hydroxyethyl)cyclobutane (83237-27-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 7h;

Reference yield:

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + cyclobutanone (1191-95-3) → 1-hydroxy-1-(β-hydroxyethyl)cyclobutane (83237-27-8)

Guidance literature:

diethoxyphosphoryl-acetic acid ethyl ester; cyclobutanone; With sodium hydride; In tetrahydrofuran; at 20 ℃;

With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 20 ℃;

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.tetlet.2012.02.034

upstream raw materials:

methanol

5,7-dioxaspiro<3.5>nonane

1-oxa-spiro[2.3]hexane-2-carboxylic acid ethyl ester

diethoxyphosphoryl-acetic acid ethyl ester

Downstream raw materials:

2-(1-hydroxycyclobutyl)ethyl 4-methylbenzenesulfonate

C₂₀H₂₃ClO₂S

4-oxa-5-phenylspiro[3.4]octane

Refernces

• 1、 -. "OXADIAZOLIDINEDIONE COMPOUND". Page/Page column 23. . Retrieved 2009/01/24.