Noroxycodone HCl

Base Information

• Chemical Name: Noroxycodone HCl
• CAS No.: 52446-25-0
• Molecular Formula: C17H19NO4.ClH
• Molecular Weight: 337.79800
• Mol file: 52446-25-0.mol

Synonyms:Noroxycodone Hydrochloride;

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Chemical Property of Noroxycodone HCl

Chemical Property:

• Flash Point: 9℃
• PSA: 67.79000
• LogP: 1.83680
• Storage Temp.: ?20°C

Purity/Quality:

Safty Information:

• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 7-16-36/37-45

MSDS Files:

Useful:

Technology Process of Noroxycodone HCl

There total 7 articles about Noroxycodone HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(5aR,6R,8aS,8a1S,11aR)-2-methoxy-5,5a,9,10-tetrahydro-7H-6,8a1-ethano-furo [2',3',4',5':4,5]phenanthro[9,8a-d]oxazol-11(11aH)-one (848489-82-7) → noroxyoxycodone hydrochloride (52446-25-0)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 40 ℃; for 2h; under 75.0075 Torr; Reflux; Inert atmosphere;

DOI:10.1002/chem.201905505

Reference yield: 57.0%

C20H22ClNO6 (958292-90-5) → noroxyoxycodone hydrochloride (52446-25-0)

Guidance literature:

With isopropyl alcohol; In water; acetonitrile; at 0 - 25 ℃; for 20 - 25h;

Reference yield: 55.0%

oxycodone hydrochloride (124-90-3) → noroxyoxycodone hydrochloride (52446-25-0)

Guidance literature:

oxycodone hydrochloride; With carbonochloridic acid 1-chloro-ethyl ester; sodium carbonate; In DCM; for 24h; Heating / reflux;

With water; In tetrahydrofuran; DCM; at 20 ℃;

upstream raw materials:

oxycodone hydrochloride

Oxycodone

C₂₀H₂₂ClNO₆

noroxycodone

Downstream raw materials:

tert-butyl (4R,4aS,7R,7aR,12bS)-7-[benzyl(methyl)amino]-4a-hydroxy-9-methoxy-1,2,4,4a,5,6,7,7a-octahydro-3H-4,12-methanobenzofuro[3,2-e]isoquinoline-3-carboxylate

Refernces

• 1、 -. "PROCESSES FOR PREPARING NOR-OPIOID COMPOUNDS AND OPIOID ANTAGONISTS BY ELECTROCHEMICAL N-DEMETHYLATION". Page/Page column 33. . Retrieved 2021/12/31.
• 2、 Kok, Gaik B.,Pye, Cory C.,Singer, Robert D.,Scammells, Peter J.. "Two-step iron(0)-mediated N-demethylation of N -methyl alkaloids". experimental part. p. 4806 - 4811. Retrieved 2010/10/19.