4,6-Dichloro-3-pyridazinecarboxylic acid

Base Information

• Chemical Name: 4,6-Dichloro-3-pyridazinecarboxylic acid
• CAS No.: 1040246-87-4
• Molecular Formula: C5H2Cl2N2O2
• Molecular Weight: 192.989
• Mol file: 1040246-87-4.mol

Synonyms:4,6-dichloropyridazine-3-carboxylic acid; 4,6-Dichloro-pyridazin-3-carboxylic acid; ,6-Dichloro-3-pyridazinecarboxylic acid; EOS-61511

Chemical Property of 4,6-Dichloro-3-pyridazinecarboxylic acid

Chemical Property:

• Boiling Point: 436.5±40.0 °C(Predicted)
• PKA: 1.31±0.25(Predicted)
• PSA: 63.08000
• Density: 1.718±0.06 g/cm3(Predicted)
• LogP: 1.48160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

4,6-Dichloro-3-pyridazinecarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4,6-Dichloro-3-pyridazinecarboxylic Acid is an intermediate in preparation of N-Heteroarylsulfonamide derivative in the study of treatment of hyperproliferative diseases.

Technology Process of 4,6-Dichloro-3-pyridazinecarboxylic acid

There total 1 articles about 4,6-Dichloro-3-pyridazinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4,6-dichloro-pyridazine-3-carboxylic acid methyl ester (372118-01-9) → 4,6-dichloropyridazine-3-carboxylic acid (1040246-87-4)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 0 ℃; for 0.666667h;

Reference yield:

4,6-dichloropyridazine-3-carboxylic acid (1040246-87-4) + 4-bromo-2-fluoroaniline (367-24-8) → 4-(4-bromo-2-fluorophenylamino)-6-chloropyridazine-3-carboxylic acid (1040246-88-5)

Guidance literature:

4-bromo-2-fluoroaniline; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

4,6-dichloropyridazine-3-carboxylic acid; In tetrahydrofuran; hexane; at 20 ℃; for 18h;

With hydrogenchloride; water; more than 3 stages;

upstream raw materials:

4,6-dichloro-pyridazine-3-carboxylic acid methyl ester

Downstream raw materials:

4-(4-bromo-2-fluorophenylamino)-6-chloropyridazine-3-carboxylic acid

Refernces

• 1、 -. "NITROGEN-CONTAINING HETEROCYCLIC COMPOUND". Paragraph 0391. . Retrieved 2015/11/16.