4-Amino-[2,3'-bithiophene]-5-carboxamide

Base Information

• Chemical Name: 4-Amino-[2,3'-bithiophene]-5-carboxamide
• CAS No.: 354812-17-2
• Molecular Formula: C9H8N2OS2
• Molecular Weight: 224.3
• European Community (EC) Number: 687-120-2
• UNII: EU3S753TY9
• DSSTox Substance ID: DTXSID001257563
• Nikkaji Number: J1.952.182F
• Wikidata: Q27164200
• ChEMBL ID: CHEMBL193093
• Mol file: 354812-17-2.mol

Synonyms:SC 514;SC-514;SC514 cpd

Chemical Property of 4-Amino-[2,3'-bithiophene]-5-carboxamide

Chemical Property:

• Melting Point: 209-211°C
• Boiling Point: 399.2oC at 760 mmHg
• Flash Point: 195.2oC
• PSA: 125.59000
• Density: 1.45g/cm3
• LogP: 3.43920
• Storage Temp.: Store at +4°C
• Solubility.: DMSO: soluble10mg/mL, clear
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 224.00780523
• Heavy Atom Count: 14
• Complexity: 237

Purity/Quality:

98%Min ^*data from raw suppliers

SC-514 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC=C1C2=CC(=C(S2)C(=O)N)N
• Description: SC-514 (354812-17-2) is a reversible, competitive inhibitor of IKK2 (IC50 = 11.2 μM). Has not been demonstrated to inhibit other IKK isoforms, or other kinases. SC-514 displays dose-dependent inhibition of the transcription of NF-κB dependent genes in cell culture.1
• Uses: A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12 for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12 μM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 μM). Shown to specifically block NF-kB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF.