HexanaMide, 3-aMino-N-cyclopropyl-2-hydroxy-, Monohydrochloride

Base Information

• Chemical Name: HexanaMide, 3-aMino-N-cyclopropyl-2-hydroxy-, Monohydrochloride
• CAS No.: 1166397-39-2
• Molecular Formula: C9H19ClN2O2
• Molecular Weight: 222.71236
• Mol file: 1166397-39-2.mol

Synonyms:3-Amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride;HexanaMide, 3-aMino-N-cyclopropyl-2-hydroxy-, Monohydrochloride

Chemical Property of HexanaMide, 3-aMino-N-cyclopropyl-2-hydroxy-, Monohydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of HexanaMide, 3-aMino-N-cyclopropyl-2-hydroxy-, Monohydrochloride

There total 34 articles about HexanaMide, 3-aMino-N-cyclopropyl-2-hydroxy-, Monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

→ (2S,3S)-N-cyclopropyl-3-amino-2-hydroxyhexanoic acid amide hydrochloride (944716-73-8,1166397-39-2)

Guidance literature:

In hexane; isopropyl alcohol; at 0 - 60 ℃; for 6h; Purification / work up;

Reference yield: 90.0%

tert-butyl (2R,3S)-1-(cyclopropylamino)-3-((R)-1,1-dimethylethylsulfanamido)-1-oxohexan-2-ylcarbonate → (2R,3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride (1166397-39-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h; stereoselective reaction;

Reference yield: 84.0%

C9H16N4O2 → (2S,3S)-N-cyclopropyl-3-amino-2-hydroxyhexanoic acid amide hydrochloride (944716-73-8,1166397-39-2)

Guidance literature:

C₉H₁₆N₄O₂; With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2.5h; under 750.075 Torr;

With hydrogenchloride; In methanol; water;

DOI:10.1002/ejoc.201403069

upstream raw materials:

(3S,3S)-N-cyclopropyl-3-(tert-butoxycarbonyl)amino-2-hydroxyhexanoic acid amide

(2S,3S)-N-cyclopropyl-3-(tert-butoxycarbonyl)amino-2-hydroxyhexanoic acid amide

acetic acid (2S)-2-tert-butoxycarbonylamino-1-cyclopropylcarbamoylpentyl ester

N-tert-butoxycarbonyl-L-norvaline

Downstream raw materials:

C₃₆H₅₅N₇O₆

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Refernces

• 1、 Zhang, Fan,Wen, Xiaoan,Xu, Qing-Long,Sun, Hongbin. "Asymmetric synthesis of 3,4-disubstituted proline derivatives: Application in synthesis of hepatitis C virus protease inhibitor telaprevir". . p. 8101 - 8109. Retrieved 2014.
• 2、 -. "PROCESS FOR PREPARING ALPHA-HYDROXY-BETA-AMINO ACID DERIVATIVES". Paragraph 0115; 0145; 0148; 0149; 0150. . Retrieved 2016/12/01.