Edoxaban (tosylate monohydrate)

Base Information

• Chemical Name: Edoxaban (tosylate monohydrate)
• CAS No.: 1229194-11-9
• Molecular Formula: C31H40ClN7O8S2
• Molecular Weight: 738.28
• Mol file: 1229194-11-9.mol

Synonyms:Edoxaban Tosylate Monohydrate; Edoxaban(tosylate Monohydrate); Edoxaban4-methylbenzenesulfonate, hydrate (1:1:1)

Chemical Property of Edoxaban (tosylate monohydrate)

Chemical Property:

• PSA: 236.85000
• LogP: 4.34050
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Very Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)

Purity/Quality:

99% ^*data from raw suppliers

Edoxaban Tosylate Monohydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Edoxaban is an anticoagulant drug which acts as a direct factor Xa inhibitor.
• Clinical Use: Daichi Sankyo’s edoxaban tosilate is an orally administered coagulation factor Xa inhibitor that was approved and launched in Japan for the preventive treatment of venous thromboembolic events (VTE) in patients undergoing total knee arthroplasty, total hip arthroplasty, or hip fracture surgery. Edoxaban has been shown to have a rapid onset of anticoagulant effect due to short Tmax (1–2 h) after dosing and sustained for up to 24 h post-dose. Marketed under the brand name Lixiana, it is currently in phase III studies in the US for the prevention of stroke and systemic embolic events in patients with atrial fibrillation (AF) and venous thromboembolism (VTE).
• Drug interactions: Potentially hazardous interactions with other drugsAnalgesics: increased risk of bleeding with NSAIDs and high dose aspirin; increased risk of haemorrhage with IV diclofenac and ketorolac - avoidAnti-arrhythmics: concentration increased by dronedarone (reduce edoxaban dose)Antibacterials: concentration increased by erythromycin (reduce edoxaban dose); concentration reduced by rifampicin.Anticoagulants: increased risk of haemorrhage with other anticoagulants - avoid.Antidepressants: concentration possibly reduced by St John’s wort.Antiepileptics: concentration possibly reduced by carbamazepine, fosphenytoin, phenobarbital, phenytoin and primidone.Antifungals: concentration increased by ketoconazole (reduce edoxaban dose).Ciclosporin: concentration of edoxaban increased (reduce edoxaban dose).