6-BroMo-2-chloro-8-fluoroquinazoline

Base Information

• Chemical Name: 6-BroMo-2-chloro-8-fluoroquinazoline
• CAS No.: 953039-25-3
• Molecular Formula: C8H3BrClFN2
• Molecular Weight: 261.481
• Mol file: 953039-25-3.mol

Synonyms:6-BroMo-2-chloro-8-fluoroquinazoline

Chemical Property of 6-BroMo-2-chloro-8-fluoroquinazoline

Chemical Property:

• Boiling Point: 308.8±35.0 °C(Predicted)
• PKA: -1.68±0.30(Predicted)
• PSA: 25.78000
• Density: 1.836±0.06 g/cm3(Predicted)
• LogP: 3.18480
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

6-Bromo-2-chloro-8-fluoroquinazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BroMo-2-chloro-8-fluoroquinazoline

There total 6 articles about 6-BroMo-2-chloro-8-fluoroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

6-bromo-8-fluoroquinazolin-2-ol (1036756-15-6) → 6-bromo-2-chloro-8-fluoroquinazoline (953039-25-3)

Guidance literature:

With trichlorophosphate; for 5h; Reflux;

Reference yield:

3-fluoroanthranilic acid (825-22-9) → 6-bromo-2-chloro-8-fluoroquinazoline (953039-25-3)

Guidance literature:

Multi-step reaction with 5 steps

1: N-Bromosuccinimide / dichloromethane / 2 h / 20 °C

2: borane-THF / tetrahydrofuran / 0 - 20 °C

3: manganese(IV) oxide / dichloromethane / 20 °C

4: 2 h / 180 °C

5: trichlorophosphate / 5 h / Reflux

With manganese(IV) oxide; N-Bromosuccinimide; borane-THF; trichlorophosphate; In tetrahydrofuran; dichloromethane;

Reference yield:

2-amino-5-bromo-3-fluorobenzoic acid (874784-14-2) → 6-bromo-2-chloro-8-fluoroquinazoline (953039-25-3)

Guidance literature:

Multi-step reaction with 4 steps

1: borane-THF / tetrahydrofuran / 0 - 20 °C

2: manganese(IV) oxide / dichloromethane / 20 °C

3: 2 h / 180 °C

4: trichlorophosphate / 5 h / Reflux

With manganese(IV) oxide; borane-THF; trichlorophosphate; In tetrahydrofuran; dichloromethane;

upstream raw materials:

6-bromo-8-fluoroquinazolin-2-ol

3-fluoroanthranilic acid

2-amino-5-bromo-3-fluorobenzoic acid

(2-amino-5-bromo-3-fluorophenyl)methanol

Downstream raw materials:

N-(3-(6-bromo-8-fluoroquinazolin-2-ylamino)-5-((dimethylamino)-methyl)phenyl)acetamide

Refernces

• 1、 -. "COMBINATION THERAPIES WITH IRE1 SMALL MOLECULE INHIBITORS". Paragraph 00358. . Retrieved 2020/12/01.
• 2、 -. "COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE". Page/Page column 121; 122. . Retrieved 2019/01/06.