4-oxopentanenitrile

Base Information

• Chemical Name: 4-oxopentanenitrile
• CAS No.: 927-56-0
• Molecular Formula: C5H7 N O
• Molecular Weight: 97.1167
• Hs Code.: 2926909090
• Mol file: 927-56-0.mol

Synonyms:Levulinonitrile(6CI,7CI,8CI); 2-Cyanoethyl methyl ketone; 3-Acetylpropionitrile;4-Oxopentanenitrile; 4-Oxovaleronitrile; Cyanoethyl methyl ketone; Levulinicacid nitrile; Levulonitrile; Methyl 2-cyanoethyl ketone; NSC 14520; NSC 53495

Chemical Property of 4-oxopentanenitrile

Chemical Property:

• Vapor Pressure: 0.138mmHg at 25°C
• Boiling Point: 216.7°Cat760mmHg
• Flash Point: 84.8°C
• PSA: 40.86000
• Density: 0.956g/cm³
• LogP: 0.87918

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-oxopentanenitrile

There total 19 articles about 4-oxopentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl vinyl ketone (78-94-4,25038-87-3) + 2-hydroxy-2-methylpropanenitrile (75-86-5) → levulinonitrile (927-56-0)

Guidance literature:

With Cp*2Sm(THF)2; In toluene; for 15h; Product distribution; Ambient temperature; other reagent;

DOI:10.1021/jo990030o

Reference yield: 86.0%

3-Pentenenitrile (16529-66-1) → levulinonitrile (927-56-0)

Guidance literature:

With water; oxygen; palladium dichloride; In N,N-dimethyl acetamide; at 80 ℃; for 20h; under 2280.15 Torr; Autoclave;

DOI:10.1002/anie.200905184

Reference yield: 86.0%

→ levulinonitrile (927-56-0)

Guidance literature:

upstream raw materials:

4-nitro-valeronitrile

hydrogen cyanide

potassium cyanide

methyl vinyl ketone

Downstream raw materials:

(S)-γ-valerolactone

1-methyl-1,4-butanediamine

4-oxopentanoic acid ethyl ester

levulinic acid

Refernces

• 1、 -. "METHOD FOR MANUFACTURING KETONE". Page/Page column 7-8; 9. . Retrieved 2012/08/08.
• 2、 Li, Nan,Chu, Xiusheng,Liu, Xiaojun,Li, Ding. "Probing the active site of rat porphobilinogen synthase using newly developed inhibitors". scheme or table. p. 33 - 40. Retrieved 2009/05/30.