N-Cyclohexyl-N-methyl-p-toluenesulfonamide

Base Information

• Chemical Name: N-Cyclohexyl-N-methyl-p-toluenesulfonamide
• CAS No.: 57186-74-0
• Molecular Formula: C14H21NO2S
• Molecular Weight: 267.392
• Mol file: 57186-74-0.mol

Synonyms:N-Cyclohexyl-N,4-dimethylbenzenesulfonamide;N-Cyclohexyl-N-methyl-p-toluenesulfonamide

Chemical Property of N-Cyclohexyl-N-methyl-p-toluenesulfonamide

Chemical Property:

• PSA: 45.76000
• LogP: 4.02900

Purity/Quality:

N-CYCLOHEXYL-N-METHYL-4-TOLUENESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Cyclohexyl-N-methyl-p-toluenesulfonamide

There total 7 articles about N-Cyclohexyl-N-methyl-p-toluenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

cyclohexene (110-83-8) + N-methyl-p-toluenesulfonylamide (640-61-9) → N-cyclohexyl-N-methyl-4-methylbenzenesulfonamide (57186-74-0)

Guidance literature:

With gallium; iodine; at 105 ℃; for 24h; Inert atmosphere; neat (no solvent);

DOI:10.1055/s-0029-1219789

Reference yield: 87.0%

cyclohexyl-methyl-amine; toluene-4-sulfonate (62316-86-3) → N-cyclohexyl-N-methyl-4-methylbenzenesulfonamide (57186-74-0)

Guidance literature:

cyclohexyl-methyl-amine; toluene-4-sulfonate; With 1,3,5-trichloro-2,4,6-triazine; In acetonitrile; at 20 ℃; for 0.5h;

With triethylamine; In acetonitrile;

DOI:10.1055/s-0029-1217020

Reference yield: 72.0%

N,N-dimethyl-cyclohexanamine (98-94-2) + p-toluenesulfonyl chloride (98-59-9) → N-cyclohexyl-N-methyl-4-methylbenzenesulfonamide (57186-74-0)

Guidance literature:

With sodium sulfate; In water; at 20 ℃; for 3.2h; Electrochemical reaction;

DOI:10.1039/c7gc03141f

upstream raw materials:

cyclohexene

N-methyl-p-toluenesulfonylamide

cyclohexyl-methyl-amine; toluene-4-sulfonate

cyclohexane

Refernces

• 1、 Sheykhan,Khani,Abbasnia,Shaabanzadeh,Joafshan. "An approach to C-N activation: Coupling of arenesulfonyl hydrazides and arenesulfonyl chlorides with: Tert -amines via a metal-, oxidant- and halogen-free anodic oxidation". supporting information. p. 5940 - 5948. Retrieved 2017/12/26.
• 2、 Tran, Ba L.,Li, Bijie,Driess, Matthias,Hartwig, John F.. "Copper-catalyzed intermolecular amidation and imidation of unactivated alkanes". supporting information. p. 2555 - 2563. Retrieved 2014/03/21.