Acetamide, N-methyl-N-(2-methylphenyl)-

Base Information

• Chemical Name: Acetamide, N-methyl-N-(2-methylphenyl)-
• CAS No.: 29823-47-0
• Molecular Formula: C10H13 N O
• Molecular Weight: 163.219
• Mol file: 29823-47-0.mol

Synonyms:Acetamide,N-benzyl-N-methyl- (6CI,7CI,8CI); N-Benzyl-N-methylacetamide;N-Methyl-N-(phenylmethyl)acetamide; N-Methyl-N-benzylacetamide

Chemical Property of Acetamide, N-methyl-N-(2-methylphenyl)-

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 20.31000
• Density: g/cm³
• LogP: 1.66490

Purity/Quality:

N-Benzyl-N-methylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Benzyl-N-methylacetamide is used as a reagent in the synthesis of arylaminopyrazole derivatives as 11β-HSD1 inhibitors.

Technology Process of Acetamide, N-methyl-N-(2-methylphenyl)-

There total 58 articles about Acetamide, N-methyl-N-(2-methylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

trimethyl phosphite (512-56-1) + N-(phenylmethyl)acetamide (588-46-5) → N-benzyl-N-methylacetamide (29823-47-0)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at 0 - 75 ℃; for 24h;

DOI:10.1055/a-1504-8366

Reference yield: 99.0%

vinyl acetate (108-05-4,9003-20-7) + benzyl-methyl-amine (103-67-3) → N-benzyl-N-methylacetamide (29823-47-0)

Guidance literature:

With immobilization of Candida cylindracea lipase; In hexane; at 55 ℃; for 13h;

DOI:10.1016/j.procbio.2013.06.009

Reference yield: 98.0%

acetic anhydride (108-24-7) + benzyl-methyl-amine (103-67-3) → N-benzyl-N-methylacetamide (29823-47-0)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In dichloromethane; for 2h; Ambient temperature;

DOI:10.1016/S0040-4039(99)00229-4

upstream raw materials:

N-methyl-N-benzylglycine

acetic anhydride

benzyl-methyl-amine

Acetyl bromide

Downstream raw materials:

1-piperidin-1-yl-ethanone

N-acetyl-N-methylbenzamide

benzyl-methyl-amine

N-methyl-N-(4-sulfamoylbenzyl)acetamide

Refernces

• 1、 Petride, Horia,Florea, Cristina,H?rtopeanu, Anca,Stavarache, Cristina. "RuO4-mediated oxidation of tertiary amines. stereoelectronic effects". . p. 89 - 96. Retrieved 2021/02/05.
• 2、 -. "COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY". Page/Page column 478; 479. . Retrieved 2019/02/13.