4-hydroxy-N,N-diphenyl-(4R)-2-Pentynamide

Base Information

• Chemical Name: 4-hydroxy-N,N-diphenyl-(4R)-2-Pentynamide
• CAS No.: 899809-61-1
• Molecular Formula: C17H15NO2
• Molecular Weight: 265.312
• Mol file: 899809-61-1.mol

Synonyms:4-hydroxy-N,N-diphenyl-(4R)-2-Pentynamide;(R)-4-hydroxy-N,N-diphenylpent-2-ynaMide;4-Hydroxy-pent-2-ynoic acid diphenylamide;(4R)-4-Hydroxy-N,N-diphenyl-2-pentynamide

Chemical Property of 4-hydroxy-N,N-diphenyl-(4R)-2-Pentynamide

Chemical Property:

• Boiling Point: 411.9±47.0 °C(Predicted)
• PKA: 13.24±0.20(Predicted)
• PSA: 40.54000
• Density: 1 +-.0.06 g/cm3(Predicted)
• LogP: 2.73550
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

(R)-4-Hydroxy-N,N-diphenylpent-2-ynamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-hydroxy-N,N-diphenyl-(4R)-2-Pentynamide

There total 4 articles about 4-hydroxy-N,N-diphenyl-(4R)-2-Pentynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

C7H13LiOSi (416844-85-4) + N,N-diphenylimidazole-1-carboxamide (2875-79-8) → (R,Z)-4-hydroxy-N,N-diphenylpent-2-ynamide (899809-61-1)

Guidance literature:

C₇H₁₃LiOSi; N,N-diphenylimidazole-1-carboxamide; In tetrahydrofuran; hexane; toluene;

With sulfuric acid; In tetrahydrofuran; hexane; water; toluene; at 5 - 25 ℃; for 1h;

Reference yield:

C19H17NO3 (899809-73-5) → (R,Z)-4-hydroxy-N,N-diphenylpent-2-ynamide (899809-61-1)

Guidance literature:

With methanol; sodium hydrogencarbonate; at 5 - 10 ℃; for 6.5h;

Reference yield:

C28H27NO5 → 3-(1,4-dioxaspiro[4.5]dec-7-en-7-yl)acrylic acid methyl ester (226916-17-2) + (R,Z)-4-hydroxy-N,N-diphenylpent-2-ynamide (899809-61-1)

Guidance literature:

With methanol; potassium hydrogencarbonate; at 0 ℃; for 16h;

upstream raw materials:

C₁₉H₁₇NO₃

C₇H₁₃LiOSi

N,N-diphenylimidazole-1-carboxamide

C₁₉H₁₇NO₃

Downstream raw materials:

(R,Z)-4-hydroxy-N,N-diphenylpent-2-enamide

C₂₆H₂₄N₂O₅

C₂₉H₃₄N₂O₅

C₂₉H₃₂N₂O₅

Refernces

• 1、 -. "AN EXO-SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS". Page/Page column 27; 28. . Retrieved 2008/06/13.
• 2、 -. "PREPARATION OF CHIRAL PROPARGYLIC ALCOHOL AND ESTER INTERMEDIATES OF HIMBACINE ANALOGS". Page/Page column 28-30. . Retrieved 2008/06/13.