Methyl 2-(5-Methylpyridin-2-yl)acetate

Base Information

• Chemical Name: Methyl 2-(5-Methylpyridin-2-yl)acetate
• CAS No.: 19946-10-2
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Hs Code.: 2933399090
• Mol file: 19946-10-2.mol

Synonyms:Methyl 2-(5-Methylpyridin-2-yl)acetate

Chemical Property of Methyl 2-(5-Methylpyridin-2-yl)acetate

Chemical Property:

• PSA: 39.19000
• LogP: 1.10550
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

Methyl2-(5-methylpyridin-2-yl)acetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-(5-Methylpyridin-2-yl)acetate

There total 7 articles about Methyl 2-(5-Methylpyridin-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

3-picoline-N-oxide (1003-73-2) + ketene t-butyldimethylsilyl methyl acetal (77086-38-5) → methyl 2-(5-methylpyridin-2-yl)acetate (19946-10-2) + methyl 2-(3-methylpyridin-2-yl)acetate (1092477-78-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; at 25 ℃; for 0.0333333h;

DOI:10.1021/ol501359r

Reference yield: 31.0%

dimethyl 2-(5-methylpyridin-2-yl)malonate → methyl 2-(5-methylpyridin-2-yl)acetate (19946-10-2)

Guidance literature:

With water; lithium chloride; In dimethyl sulfoxide; at 120 ℃; for 5h; Inert atmosphere;

DOI:10.1002/anie.201506868

Reference yield:

methanol (67-56-1) + (5-methylpyridin-2-yl)acetic acid (848093-05-0) → methyl 2-(5-methylpyridin-2-yl)acetate (19946-10-2)

Guidance literature:

With dmap; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 45 ℃;

DOI:10.1021/acs.joc.8b02883

upstream raw materials:

3-picoline-N-oxide

ketene t-butyldimethylsilyl methyl acetal

2,5-dimethylpyridine

methyl chloroformate

Refernces

• 1、 Chen, Zhengwang,Liu, Tanggao,Ma, Xiaoyue,Liang, Pei,Long, Lipeng,Ye, Min. "A One-Pot Sonogashira Coupling and Annulation Reaction: An Efficient Route toward 4 H -Quinolizin-4-ones". supporting information. p. 863 - 867. Retrieved 2019/04/25.
• 2、 Kim, Ju Hyun,Gensch, Tobias,Zhao, Dongbing,Stegemann, Linda,Strassert, Cristian A.,Glorius, Frank. "RhIII-Catalyzed C-H Activation with Pyridotriazoles: Direct Access to Fluorophores for Metal-Ion Detection". supporting information. p. 10975 - 10979. Retrieved 2015/09/15.