BMX-IN-1

Base Information

• Chemical Name: BMX-IN-1
• CAS No.: 1431525-23-3
• Molecular Formula: C29H24N4O4S
• Molecular Weight: 524.59026
• Mol file: 1431525-23-3.mol

Synonyms:BMX kinase inhibitor;BMX-IN-1;N-(2-Methyl-5-(9-(4-(MethylsulfonaMido)phenyl)-2-oxobenzo[h][1,6]naphthyridin-1(2H)-yl)phenyl)acrylaMide;N-[2-Methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-2-propenamide;henyl]-

Chemical Property of BMX-IN-1

Chemical Property:

• Solubility.: insoluble in H2O; insoluble in EtOH; ≥5.25 mg/mL in DMSO

Purity/Quality:

99% ^*data from raw suppliers

BMX-IN-1 ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX; IC50 = 8 nM) that targets Cys496 in the BMX ATP binding domain. It additionally targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent for inhibition of Blk, JAK3, EGFR, Itk, or Tec activity. BMX-IN-1 was shown to inhibit the proliferation of Tel-BMX-transformed Ba/F3 prostate cancer cells with a GI50 value of 25 nM. Antiproliferative activity was also observed in RV-1, DU-145, PC-3, and VCAP prostate cancer cell lines (GI50s = 2.54, 4.38, 5.37, and 2.46 μM, respectively).