7-HYDROXYFLAVONE

Base Information

• Chemical Name: 7-HYDROXYFLAVONE
• CAS No.: 6665-86-7
• Molecular Formula: C15H10O3
• Molecular Weight: 238.243
• Hs Code.: 29329990
• Mol file: 6665-86-7.mol

Synonyms:NSC 94258;7-Hydroxyflavone;Flavone,7-hydroxy- (7CI,8CI);

Chemical Property of 7-HYDROXYFLAVONE

Chemical Property:

• Appearance/Colour: off-white crystals
• Vapor Pressure: 1.02E-08mmHg at 25°C
• Melting Point: 245-247 °C(lit.)
• Refractive Index: 1.666
• Boiling Point: 450.1 °C at 760 mmHg
• PKA: 7.02±0.40(Predicted)
• Flash Point: 176.3 °C
• PSA: 50.44000
• Density: 1.34 g/cm³
• LogP: 3.16560
• Water Solubility.: Insoluble in water

Purity/Quality:

99% ^*data from raw suppliers

7-Hydroxyflavone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: antifungal, analgesic Reactant:Acting as a biologically valuable acceptor in O-glycosidation reactionsInvolved in synthesis of fully phosphorylated flavones for use as pancreatic cholesterol esterase inhibitorsFor O-methylation with di-Me carbonateLinked by a polymethylene chain for synthesis of α1-adrenoceptor antagonistsInvolved in Baylis-Hillman reactionsInvolved in phase-transfer catalyzed glucosylation for synthesis of glucosylated flavonoids

Technology Process of 7-HYDROXYFLAVONE

There total 77 articles about 7-HYDROXYFLAVONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

7-methoxoyflavone (22395-22-8) → 7-hydroxyflavone (6665-86-7,66585-10-2)

Guidance literature:

With boron tribromide; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1039/c5ra13912k

Reference yield: 92.0%

C18H14O5 → 7-hydroxyflavone (6665-86-7,66585-10-2)

Guidance literature:

With hydrogen bromide; In water; at 110 - 120 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c5ra24634b

Reference yield: 90.4%

2',4'-dihydroxy-4-acetophenone (89-84-9) + benzoyl chloride (98-88-4) → 7-hydroxyflavone (6665-86-7,66585-10-2)

Guidance literature:

2',4'-dihydroxy-4-acetophenone; With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; for 0.666667h; Inert atmosphere;

benzoyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 12h; Inert atmosphere;

With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 12h; Inert atmosphere; Reflux;

DOI:10.2174/1570178615666180621094529

upstream raw materials:

<4-(benzoyloxy)-2-hydroxybenzoyl>benzoylmethane

3-benzoyl-4,7-dihydroxy-coumarin

7-(benzyloxy)-2-phenyl-4H-chromen-4-one

7-hydroxy-2-phenyl-3-benzoylchromone

Downstream raw materials:

7-Butoxycarbonylmethoxy-4-oxo-2-phenyl-4H-chromen

7-dichloroacetoxy-2-phenyl-chromen-4-one

(4-oxo-2-phenyl-4H-chromen-7-yloxy)-acetic acid isopropyl ester

(4-oxo-2-phenyl-4H-chromen-7-yloxy)-acetic acid propyl ester

Refernces

• 1、 Javadi, Mahdiyeh H. S.,Iraji, Aida,Safavi, Maliheh,Montazeri, Hamed,Tarighi, Parastoo,Eftekhari, Samane,Navidpour, Latifeh,Mirfazli, Seyedeh Sara. "Design, synthesis and apoptosis inducing activity of nonsteroidal flavone-methanesulfonate derivatives on MCF-7 cell line as potential sulfatase inhibitor". . p. 1677 - 1687. Retrieved 2021/07/26.
• 2、 Son, Seung Hwan,Cho, Yang Yil,Yoo, Hyung-Seok,Lee, Soo Jin,Kim, Young Min,Jang, Hyu Jeong,Kim, Dong Hwan,Shin, Jeong-Won,Kim, Nam-Jung. "Divergent synthesis of flavones and flavanones from 2′-hydroxydihydrochalconesviapalladium(ii)-catalyzed oxidative cyclization". . p. 14000 - 14006. Retrieved 2021/04/22.