4-isobutyloxybenzyl isocyanate

Base Information

• Chemical Name: 4-isobutyloxybenzyl isocyanate
• CAS No.: 639863-75-5
• Molecular Formula: C12H15NO2
• Molecular Weight: 205.257
• Mol file: 639863-75-5.mol

Synonyms:4-isobutyloxybenzyl isocyanate;4-isobutyloxybenzyl isocyate;4-Isobutoxybenzyl isocyanate

Chemical Property of 4-isobutyloxybenzyl isocyanate

Chemical Property:

• Appearance/Colour: colorless liquid
• Boiling Point: 294.0±23.0 °C(Predicted)
• PSA: 38.66000
• Density: 1.00±0.1 g/cm3(Predicted)
• LogP: 2.55720

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-isobutyloxybenzyl isocyanate

There total 24 articles about 4-isobutyloxybenzyl isocyanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-[4-(2-methylpropoxy)phenyl]acetyl chloride (639863-90-4) → 1-(isocyanatomethyl)-4-(2-methylpropoxy)benzene (639863-75-5)

Guidance literature:

With sodium azide; In water; acetone; for 1.16667h;

Reference yield: 94.0%

2-[4-(2-methylpropoxy)phenyl]acetic acid (13362-94-2) → 1-(isocyanatomethyl)-4-(2-methylpropoxy)benzene (639863-75-5)

Guidance literature:

2-[4-(2-methylpropoxy)phenyl]acetic acid; With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; In tetrahydrofuran; at 20 ℃; for 0.416667h;

With diphenyl phosphoryl azide; In tetrahydrofuran; at -20 - 20 ℃; for 26h; Heating / reflux;

Reference yield: 87.0%

bis(trichloromethyl) carbonate (32315-10-9) + 1-[4-(2-methylpropyloxy)phenyl]methanamine (4734-09-2) → 1-(isocyanatomethyl)-4-(2-methylpropoxy)benzene (639863-75-5)

Guidance literature:

In dichloromethane; at -5 - 0 ℃; for 2h;

upstream raw materials:

2-[4-(2-methylpropoxy)phenyl]acetic acid

phosgene

4-hydroxy-benzaldehyde

4-isobutoxybenzaldehyde

Downstream raw materials:

N-(4-fluorobenzyl)-N-[1-(trifluoroacetyl)piperidin-4-yl]-N'-(4-isobutyloxybenzyl)carbamide

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

N,N'-bis(4-isobutoxybenzyl)urea

Refernces

• 1、 -. "COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES". . . Retrieved 2019/03/12.
• 2、 -. "A high-purity matching not fan selin preparation method". . . Retrieved 2019/05/22.