2-[[(4-Methoxy-3-methyl-2-pyridinyl)methyl]thio]-6-(1H-pyrrol-1-yl)-1H-benzimidazole

Base Information

• Chemical Name: 2-[[(4-Methoxy-3-methyl-2-pyridinyl)methyl]thio]-6-(1H-pyrrol-1-yl)-1H-benzimidazole
• CAS No.: 172152-35-1
• Molecular Formula: C19H18N4OS
• Molecular Weight: 350.444
• Mol file: 172152-35-1.mol

Synonyms:2-[[(4-Methoxy-3-methyl-2-pyridinyl)methyl]thio]-6-(1H-pyrrol-1-yl)-1H-benzimidazole;5-(1H-pyrrol-1-yl)-2-[(4-methoxy-3-methyl-2-pyridyl)-methylthio]-1-hydro-benzimidazole

Chemical Property of 2-[[(4-Methoxy-3-methyl-2-pyridinyl)methyl]thio]-6-(1H-pyrrol-1-yl)-1H-benzimidazole

Chemical Property:

• Boiling Point: 590.4±60.0 °C(Predicted)
• PKA: 9.26±0.10(Predicted)
• PSA: 81.03000
• Density: 1.30±0.1 g/cm3(Predicted)
• LogP: 4.35790

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Desoxy Ilaprazole is an intermediate in the synthesis of Ilaprazole (I266400), a proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer.

Technology Process of 2-[[(4-Methoxy-3-methyl-2-pyridinyl)methyl]thio]-6-(1H-pyrrol-1-yl)-1H-benzimidazole

There total 2 articles about 2-[[(4-Methoxy-3-methyl-2-pyridinyl)methyl]thio]-6-(1H-pyrrol-1-yl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.6%

5-(1H-pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol (172152-53-3) + 2-chloromethyl-4-methoxy-3-methylpyridine hydrochloride (86604-74-2) → 2-(((4-methoxy-3-methylpyridin-2-yl)methyl)thio)-5-(1H-pyrrol-1-yl)-1H-benzo[d]imidazole (172152-35-1)

Guidance literature:

With sodium hydroxide; In methanol; at 20 - 40 ℃; Temperature; Reagent/catalyst; Solvent;

Reference yield: 38.1%

cis,trans-2,5-dimethoxytetrahydrofuran (696-59-3) + 5-amino-2-[(4-methoxy-3-methyl-2-pyridyl)-methylthio]-1-hydro-benzimidazole (910664-00-5) → 2-(((4-methoxy-3-methylpyridin-2-yl)methyl)thio)-5-(1H-pyrrol-1-yl)-1H-benzo[d]imidazole (172152-35-1)

Guidance literature:

With acetic acid; at 120 ℃; for 0.0833333h;

upstream raw materials:

cis,trans-2,5-dimethoxytetrahydrofuran

5-amino-2-[(4-methoxy-3-methyl-2-pyridyl)-methylthio]-1-hydro-benzimidazole

5-(1H-pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol

2-chloromethyl-4-methoxy-3-methylpyridine hydrochloride

Refernces

• 1、 -. "Pharmaceutical composition containing ilaprazole sodium and preparation method thereof". Paragraph 0032-0034. . Retrieved 2019/01/14.
• 2、 -. "SUBSTITUTED SULFOXIDE COMPOUNDS, METHODS FOR PREPARING THE SAME AND USE THEREOF". Page/Page column 6; 13; 16-17. . Retrieved 2008/06/13.