7-BroMo-2-chlorobenzothiazole

Base Information

• Chemical Name: 7-BroMo-2-chlorobenzothiazole
• CAS No.: 1188227-29-3
• Molecular Formula: C7H3BrClNS
• Molecular Weight: 248.531
• Hs Code.: 29342000
• Mol file: 1188227-29-3.mol

Synonyms:7-BroMo-2-chlorobenzothiazole;2-Chloro-7-bromobenzothiazole;7-BroMo-2-chlorobenzo[d]thiazole

Chemical Property of 7-BroMo-2-chlorobenzothiazole

Chemical Property:

• PSA: 41.13000
• LogP: 3.71220
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

7-Bromo-2-chlorobenzothiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-BroMo-2-chlorobenzothiazole

There total 5 articles about 7-BroMo-2-chlorobenzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-mercapto-7-bromobenzothiazole → 7-bromo-2-chlorobenzothiazole (1188227-29-3)

Guidance literature:

With sulfuryl dichloride; In dichloromethane; at 20 ℃; for 1h; Cooling with ice;

DOI:10.1016/j.bmc.2015.11.011

Reference yield: 86.0%

→ 7-bromo-2-chlorobenzothiazole (1188227-29-3)

Guidance literature:

With sulfuryl dichloride; In dichloromethane; at 22 ℃; for 1h; Cooling with ice;

Reference yield:

3-bromo-2-fluorobenzenamine (58534-95-5) → 7-bromo-2-chlorobenzothiazole (1188227-29-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 3 h / 120 °C / Inert atmosphere

2: sulfuryl dichloride / dichloromethane / 1 h / 20 °C / Cooling with ice

With sulfuryl dichloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2015.11.011

upstream raw materials:

3-bromo-2-fluorobenzoic acid

3-bromo-2-fluorobenzenamine

(3-bromo-2-fluorophenyl)carbamic acid tert-butyl ester

Refernces

• 1、 Lv, Fengping,Li, Zhi-Fang,Hu, Wenhao,Wu, Xiaohua. "Small molecules enhance functional O-mannosylation of Alpha-dystroglycan". supporting information. p. 7661 - 7670. Retrieved 2015/12/18.