5-Chloro-1-methoxy-3-nitrobenzene

Base Information

• Chemical Name: 5-Chloro-1-methoxy-3-nitrobenzene
• CAS No.: 55910-07-1
• Molecular Formula: C7H6ClNO3
• Molecular Weight: 187.583
• Hs Code.: 2909309090
• Mol file: 55910-07-1.mol

Synonyms:3-Chloro-5-methoxy-1-nitrobenzene;3-Chloro-5-nitroanisole;5-Chloro-1-methoxy-3-nitrobenzene

Chemical Property of 5-Chloro-1-methoxy-3-nitrobenzene

Chemical Property:

• Melting Point: 101 °C
• Boiling Point: 280.8±20.0 °C(Predicted)
• PSA: 55.05000
• Density: 1.366±0.06 g/cm3(Predicted)
• LogP: 2.78000
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

1-Chloro-3-methoxy-5-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Chloro-1-methoxy-3-nitrobenzene

There total 8 articles about 5-Chloro-1-methoxy-3-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-chloro-5-nitrophenol (618-63-3) + dimethyl sulfate (77-78-1) → 1-chloro-3-methoxy-5-nitrobenzene (55910-07-1)

Guidance literature:

With potassium carbonate; In ethanol; at 20 ℃; for 12h; Product distribution / selectivity;

Reference yield: 78.3%

1-chloro-3,5-dinitrobenzene (618-86-0) + sodium methylate (124-41-4) → 1-chloro-3-methoxy-5-nitrobenzene (55910-07-1)

Guidance literature:

In methanol; Reflux;

Reference yield: 57.0%

methanol (67-56-1) + 1-chloro-3,5-dinitrobenzene (618-86-0) → 1-chloro-3-methoxy-5-nitrobenzene (55910-07-1)

Guidance literature:

With sodium; at 80 ℃; for 70h;

DOI:10.1002/hlca.19880710206

upstream raw materials:

1-chloro-3,5-dinitrobenzene

sodium methylate

3-methoxy-5-nitroaniline

methanol

Downstream raw materials:

3-chloro-5-nitro-phenyl trifluoromethanesulphonate

Phosphorsaeure-<5-chlor-3-nitro-phenylester>

3-chloro-2,4,5,6-tetranitro-phenol

1,3-diamino-5-hydroxytrinitrobenzene

Refernces

• 1、 -. "NEW SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS". Page/Page column 105-106. . Retrieved 2008/12/07.
• 2、 Martin, Pierre. "Synthese von natuerlichen Haloindolen via Hetero-Cope-Umlagerung von Vinyl-N-phenylhydroxamaten". . p. 344 - 347. Retrieved 2007/10/02.