Azepan-3-ylaMine dihydrochloride

Base Information

• Chemical Name: Azepan-3-ylaMine dihydrochloride
• CAS No.: 1159822-22-6
• Molecular Formula: C6H16Cl2N2
• Molecular Weight: 187.11064
• Hs Code.: 2933990090
• Mol file: 1159822-22-6.mol

Synonyms:Azepan-3-ylaMine dihydrochloride;1H-Azepin-3-amine, hexahydro-, dihydrochloride;azepan-3-amine dihydrochloride;3-AMINO-HOMOPIPERIDINE 2HCL

Chemical Property of Azepan-3-ylaMine dihydrochloride

Chemical Property:

• PSA: 38.05000
• LogP: 2.72030
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

96% purity ^*data from raw suppliers

3-Amino-homopiperidineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Azepan-3-ylaMine dihydrochloride

There total 5 articles about Azepan-3-ylaMine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.2%

C21H26N2O2 → (3S)-aminoazepine hydrochloride (1159822-22-6,334620-16-5)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; at 50 - 60 ℃; under 7500.75 Torr;

Reference yield:

(R)-benzyl azepan-3-ylcarbamate → R-3-amino-hexahydroazepine hydrochloride (1159822-22-6,334620-16-5)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 - 25 ℃; for 12h; Temperature;

Reference yield:

D-2-aminoadipic acid (7620-28-2) → R-3-amino-hexahydroazepine hydrochloride (1159822-22-6,334620-16-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sulfuric acid / 2 h / 45 °C

1.2: 2 h / 0 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / -5 - 15 °C

3.1: triethylamine / dichloromethane / 2 h / 0 °C

4.1: ammonium hydroxide / acetonitrile / 48 h / 25 °C

5.1: thionyl chloride / dichloromethane / 12 h / 0 - 25 °C

With ammonium hydroxide; lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

upstream raw materials:

D-2-aminoadipic acid

Refernces

• 1、 -. "A kind of optical active pharmaceutical process for the preparation of intermediates". Paragraph 0071; 0072. . Retrieved 2016/10/17.