5'(S)-Hydroxy SiMvastatin DISCONTINUED

Base Information

• Chemical Name: 5'(S)-Hydroxy SiMvastatin DISCONTINUED
• CAS No.: 149949-05-3
• Molecular Formula: C₂₅H₃₈O₆
• Molecular Weight: 434.573
• Mol file: 149949-05-3.mol

Synonyms:5'(S)-Hydroxy SiMvastatin DISCONTINUED;2,2-DiMethylbutanoic Acid [1S-[1α,3α,4β,7β,8β(2S*,4S*)]]-1,2,3,4,7,8-Hexahydro-4-hydroxy-3,7-diMethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl Ester;(4S)-Hydroxy Simvastatin

Chemical Property of 5'(S)-Hydroxy SiMvastatin DISCONTINUED

Chemical Property:

• PSA: 93.06000
• LogP: 3.70050

Purity/Quality:

>95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A derivative of Simvastatin. An isomer of 3’(S)-Hydroxy Simvastatin.

Technology Process of 5'(S)-Hydroxy SiMvastatin DISCONTINUED

There total 1 articles about 5'(S)-Hydroxy SiMvastatin DISCONTINUED which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

simvastatin (123049-81-0,79902-63-9) → 2,2-Dimethyl-butyric acid (2R,4S,4aS,5S,6S)-5-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2,6-dimethyl-2,3,4,4a,5,6-hexahydro-1aH-1-oxa-cyclopropa[d]naphthalen-4-yl ester + 6(S)-hydroperoxysimvastatin (149949-01-9) + 2,2-Dimethyl-butyric acid (1S,3R,4S)-4-hydroxy-8-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-3,7-dimethyl-1,2,3,4-tetrahydro-naphthalen-1-yl ester + 6(R)-<2-<8(S)-((2,2-Dimethylbutyryl)oxy)-2(S),6-dimethyl-3-oxo-1,2,3,7,8,8a(R)-hexahydronaphth-1(S)-yl>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one + 2,2-Dimethyl-butyric acid (1S,3R,4S,7S,8S)-4-hydroxy-8-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-3,7-dimethyl-1,2,3,4,7,8-hexahydro-naphthalen-1-yl ester (149949-05-3) + 2,2-Dimethyl-butyric acid (4S,4aS,5S,6S)-2-hydroperoxy-5-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2,6-dimethyl-2,3,4,4a,5,6-hexahydro-1aH-1-oxa-cyclopropa[d]naphthalen-4-yl ester

Guidance literature:

With 2,2’-azobis(4-methoxy-2,4-dimethyl)valeronitrile; oxygen; In 1,2-dichloro-ethane; at 35 ℃; for 6h; Kinetics; Mechanism; Product distribution;

DOI:10.1016/S0040-4020(01)81275-8

upstream raw materials:

simvastatin

Refernces