Formoterol

Base Information Edit

Chemical Name:Formoterol
CAS No.:128954-45-0
Molecular Formula:C19H24N2O4
Molecular Weight:344.411
Hs Code.:
European Community (EC) Number:615-991-0
DSSTox Substance ID:DTXSID20860603
Wikipedia:Formoterol
Wikidata:Q637247
NCI Thesaurus Code:C65754,C81648
RXCUI:25255
Pharos Ligand ID:8VKJ7WK1RNCS
Metabolomics Workbench ID:145711
ChEMBL ID:CHEMBL1256786
Mol file:128954-45-0.mol

Synonyms:3-formylamino-4-hydroxy-alpha-(N-1-methyl-2-p-methoxyphenethylaminomethyl)benzyl alcohol.hemifumarate;arformoterol;BD 40A;eformoterol;Foradil;formoterol;formoterol fumarate;formoterol fumarate, ((R*,R*)-(+-))-isomer;formoterol, ((R*,R*)-(+-))-isomer;Oxis

Suppliers and Price of Formoterol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Formoterol(mixtureofDiastereomers)
10mg
$ 1455.00

Total 3 raw suppliers

Chemical Property of Formoterol Edit

Chemical Property:

PSA：94.31000
LogP:3.26370
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:1.8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:344.17360725
Heavy Atom Count:25
Complexity:388

Purity/Quality:

98% ^*data from raw suppliers

Formoterol(mixtureofDiastereomers) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O
Recent ClinicalTrials:Replication of the P04334 Asthma Trial in Healthcare Claims Data
Recent EU Clinical Trials:CONNected Electronic Inhalers Asthma Control Trial 3 (“CONNECT 3”), a 24-Week Treatment, Multicenter, Open-Label, Randomized, Parallel Group Comparison Study of Standard of Care Treatment Versus the Budesonide/Formoterol Digihaler Digital System, to Optimize Outcomes in Adult Patients with Asthma
Recent NIPH Clinical Trials:A Randomized, Double-Blind, Double Dummy, Parallel Group, Multicenter Variable Length Study to Assess the Efficacy and Safety of PT010 Relative to PT009 and Symbicort in Adult and Adolescent Participants With Inadequately Controlled Asthma
Uses Formoterol is a selective β2-adrenergic receptor agonist. Formoterol is used as an antiasthmatic.

Technology Process of Formoterol

There total 10 articles about Formoterol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 43229-70-5
N-[5-(2-{benzyl[2-(4-methoxyphenyl)-1-methylethyl]amino}-1-hydroxyethyl)-2-benzyloxyphenyl]formamide

: 128954-45-0,67346-49-0
formoterol

Guidance literature:: With sodium dihydrogenphosphate; formic acid; ammonium formate; palladium(II) hydroxide; In tetrahydrofuran; at 24 ℃; Solvent; Reagent/catalyst; Temperature;

Reference yield: 85.51%

: 43229-69-2
N-[5-(2-{Benzyl-[2-(4-methoxy-phenyl)-1-methyl-ethyl]-amino}-1-hydroxy-ethyl)-2-benzyloxy-phenyl]-formamide; compound with (E)-but-2-enedioic acid

: 128954-45-0,67346-49-0
formoterol

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; at 30 - 35 ℃; under 3750.38 - 3900.39 Torr; Reagent/catalyst; Solvent;