[1]Benzothieno[2,3-d]pyridazine

Base Information

• Chemical Name: [1]Benzothieno[2,3-d]pyridazine
• CAS No.: 244-92-8
• Molecular Formula: C₁₀H₆N₂S
• Molecular Weight: 186.237
• Mol file: 244-92-8.mol

Synonyms:[1]Benzothieno[2,3-d]pyridazine

Chemical Property of [1]Benzothieno[2,3-d]pyridazine

Chemical Property:

• Melting Point: 128 - 129 °C
• PSA: 54.02000
• LogP: 2.84450

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1]Benzothieno[2,3-d]pyridazine

There total 13 articles about [1]Benzothieno[2,3-d]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

benzothiophene-3-carboxaldehyde (5381-20-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → benzo[4,5]thieno[2,3-d]pyridazine (244-92-8)

Guidance literature:

benzothiophene-3-carboxaldehyde; With n-butyllithium; N,N',N'-trimethylenediamine; In tetrahydrofuran; hexane; at -20 ℃; for 0.75h; Inert atmosphere;

With n-butyllithium; In tetrahydrofuran; hexane; at -20 ℃; for 2h; Inert atmosphere;

N,N-dimethyl-formamide; Further stages;

DOI:10.1021/ol301167q

Reference yield: 50.0%

3,4-dihydrobenzo[4,5]thieno[2,3-d]pyridazine (541506-51-8) → benzo[4,5]thieno[2,3-d]pyridazine (244-92-8)

Guidance literature:

With air; for 96h;

DOI:10.1016/S0040-4020(03)00074-7

Reference yield:

benzo[b]thiophene-2,3-dicarbaldehyde (7137-33-9) → benzo[4,5]thieno[2,3-d]pyridazine (244-92-8)

Guidance literature:

With hydrazine hydrate; In ethanol; Heating;

DOI:10.1016/0040-4020(72)80091-7

upstream raw materials:

benzo[b]thiophene-2,3-dicarbaldehyde

4-hydrazino-benzo[4,5]thieno[2,3-d]pyridazine

benzo[4,5]thieno[2,3-d]pyridazine-4-carboxylic acid

benzo[4,5]thieno[2,3-d]pyridazine-1-carboxylic acid

Downstream raw materials:

2-benzoyl-1,2-dihydro-benzo[4,5]thieno[2,3-d]pyridazine-1-carbonitrile

Refernces

• 1、 Sha, Chin-Kang,Hsu, Hsi-Yen,Cheng, Su-Ya,Kuo, Yuan-Liang. "Synthesis and Diels-Alder reactions of the benzo[4,5]thieno [2,3-c]pyrrole ring system". . p. 1477 - 1481. Retrieved 2007/10/03.