Ibuprofen piconol

Base Information

• Chemical Name: Ibuprofen piconol
• CAS No.: 82962-57-0
• Molecular Formula: C₁₉H₂₃NO₂
• Molecular Weight: 297.397
• Mol file: 82962-57-0.mol

Synonyms:pyridin-2-ylmethyl 2-[4-(2-methylpropyl)phenyl]propanoate

Chemical Property of Ibuprofen piconol

Chemical Property:

• Boiling Point: 402.9±30.0 °C(Predicted)
• PKA: 3.36±0.12(Predicted)
• Density: 1.063±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ibuprofen piconol

There total 4 articles about Ibuprofen piconol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-Hydroxymethylpyridine (586-98-1) + ibuprofen (15687-27-1,58560-75-1) → ibuprofen piconol (112017-99-9,64622-45-3,82962-58-1,82962-57-0)

Guidance literature:

With Montmorillonite clay K-10; In toluene; for 18h; Heating;

DOI:10.1081/SCC-200048418

Reference yield: 82.0%

2-Hydroxymethylpyridine (586-98-1) + (+/-)-ibuprofen methyl ester (61566-34-5) → ibuprofen piconol (112017-99-9,64622-45-3,82962-58-1,82962-57-0)

Guidance literature:

With oxo[hexa(trifluoroacetato)]tetrazinc; C₁₉H₂₄N₄O; In 5,5-dimethyl-1,3-cyclohexadiene; for 38h; Reflux;

Reference yield: 53.0%

2-Hydroxymethylpyridine (586-98-1) + ibuprofen (15687-27-1,58560-75-1) + 1,3-Dicyclohexylurea (2387-23-7) → C26H40O2N2 + ibuprofen piconol (112017-99-9,64622-45-3,82962-58-1,82962-57-0)

Guidance literature:

In dichloromethane; cooling;

upstream raw materials:

2-Hydroxymethylpyridine

ibuprofen

1,3-Dicyclohexylurea

(+/-)-2-(4-isobutylphenyl)propanoyl chloride

Refernces

• 1、 -. "Method for producing ester group-containing compound being useful for optical material applications such as optical compensation films". Paragraph 0215-0218. . Retrieved 2019/07/16.
• 2、 Haricharan Raju,Anand, C. Vijay,Dubey,Acharyulu, Palle V. R.. "Alterntnate routes for the synthesis of ibuprofen piconol". . p. 170 - 172. Retrieved 2008/02/09.