pirodavir

Base Information

• Chemical Name: pirodavir
• CAS No.: 124436-59-5
• Molecular Formula: C₂₁H₂₇N₃O₃
• Molecular Weight: 369.464
• Mol file: 124436-59-5.mol

Synonyms:Ethyl4-[2-[1-(6-methyl-3-pyridazinyl)-4-piperidinyl]ethoxy]benzoate; Pirodavir; R77975

Chemical Property of pirodavir

Chemical Property:

• Vapor Pressure: 4.28E-13mmHg at 25°C
• Melting Point: 124-125℃
• Boiling Point: 572°Cat760mmHg
• Flash Point: 299.8°C
• PSA: 64.55000
• Density: 1.137g/cm³
• LogP: 3.71220
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

R77975 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Pirodavir is a broad-spectrum antipicornaviral agent. It is active against 80 typed (MICs = 0.001-14.4 μg/ml) and one untyped rhinovirus strain (MIC = 0.002 μg/ml) and is active against both group A and group B serotypes. It is also active against serotypes of coxsackievirus, poliovirus, and echovirus enteroviruses (MICs = 0.018-8.5, 0.025-0.27, and 0.019-1.3 μg/ml, respectively).
• Uses: Pirodavir is used to modulate lipophilicity in human rhinovirus capsid binders. It also is used in order to identify potential ativiral agents. R 77975 is used to modulate lipophilicity in human rhinovirus capsid binders. It also is used in order to identify potential ativiral agents.

Technology Process of pirodavir

There total 2 articles about pirodavir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Ethyl 4-hydroxybenzoate (120-47-8) + 3-methyl-6-[4-(2-chloroethyl)-1-piperidynyl]pyridazine (124438-52-4) → pirodavir (124436-59-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃;

DOI:10.1021/jm0202876

Reference yield:

→ pirodavir (124436-59-5)

Guidance literature:

upstream raw materials:

Ethyl 4-hydroxybenzoate

3-methyl-6-[4-(2-chloroethyl)-1-piperidynyl]pyridazine

Refernces

• 1、 -. "Antipicornaviral pyridazinamines". . . Retrieved 2008/06/13.