Debio-1347

Base Information

• Chemical Name: Debio-1347
• CAS No.: 1265229-25-1
• Molecular Formula: C20H16N6O
• Molecular Weight: 356.38
• Mol file: 1265229-25-1.mol

Synonyms:Debio-1347;FF284;CH5183284 (Debio-1347);(5-amino-1-(2-methyl-3H-benzo[d]imidazol-5-yl)-1H-pyrazol-4-yl)(1H-indol-2-yl)methanone;CH5183284

Chemical Property of Debio-1347

Chemical Property:

• Appearance/Colour: White Solid
• Boiling Point: 775.5±55.0 °C(Predicted)
• PKA: 10.51±0.10(Predicted)
• PSA: 105.38000
• Density: 1.51±0.1 g/cm3(Predicted)
• LogP: 3.93270
• Solubility.: ≥35.6 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O

Purity/Quality:

99% ^*data from raw suppliers

CH5183284 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: CH5183284 is an orally available and selective FGFR (fibroblast growth factor receptor) inhibitor acting on FGFR 1, 2, and 3.

Technology Process of Debio-1347

There total 4 articles about Debio-1347 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

[5-amino-1-(2-methyl-1H-benzimidazol-5-yl)-1H-pyrazol-4-yl]-(1-benzenesulfonyl-1H-indol-2-yl) methanone (1265231-79-5) → [5-amino-1-(2-methyl-1H-benzimidazol-5-yl)-1H-pyrazol-4-yl](1H-indol-2-yl)methanone (1265229-25-1)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 20 ℃; for 2h;

Reference yield:

3-(dimethylamino)-2-(1-(phenylsulfonyl)-1H-indole-2-carbonyl)acrylonitrile (1265231-91-1) → [5-amino-1-(2-methyl-1H-benzimidazol-5-yl)-1H-pyrazol-4-yl](1H-indol-2-yl)methanone (1265229-25-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 20 °C / Reflux

2: sodium hydroxide; water / ethanol / 2 h / 20 °C

With water; sodium hydroxide; In ethanol;

Reference yield:

3-(1-benzenesulfonyl-1H-indol-2-yl)-3-oxo-propionitrile (1265234-00-1) → [5-amino-1-(2-methyl-1H-benzimidazol-5-yl)-1H-pyrazol-4-yl](1H-indol-2-yl)methanone (1265229-25-1)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 20 °C

2: ethanol / 20 °C / Reflux

3: sodium hydroxide; water / ethanol / 2 h / 20 °C

With water; sodium hydroxide; In tetrahydrofuran; ethanol;

upstream raw materials:

[5-amino-1-(2-methyl-1H-benzimidazol-5-yl)-1H-pyrazol-4-yl]-(1-benzenesulfonyl-1H-indol-2-yl) methanone

3-(dimethylamino)-2-(1-(phenylsulfonyl)-1H-indole-2-carbonyl)acrylonitrile

3-(1-benzenesulfonyl-1H-indol-2-yl)-3-oxo-propionitrile

ethyl 1-(phenylsulfonyl)-1H-indole-2-carboxylate

Refernces