Nadolol

Base Information

• Chemical Name: Nadolol
• CAS No.: 42200-33-9
• Molecular Formula: C17H27NO4
• Molecular Weight: 309.406
• Hs Code.: 2922190900
• European Community (EC) Number: 255-706-3
• NSC Number: 758430
• UNII: FEN504330V
• Wikipedia: Nadolol
• Wikidata: Q424952
• NCI Thesaurus Code: C29280
• RXCUI: 7226
• Pharos Ligand ID: BKCJ13G4JAWC,BKCTRWF9CSHJ
• Metabolomics Workbench ID: 43417
• ChEMBL ID: CHEMBL649
• Mol file: 42200-33-9.mol

Synonyms:Corgard;Nadolol;Solgol;SQ 11725;SQ-11725;SQ11725

Chemical Property of Nadolol

Chemical Property:

• Appearance/Colour: White Solid
• Vapor Pressure: 6.54E-12mmHg at 25°C
• Melting Point: 125-130 °C
• Refractive Index: 1.573
• Boiling Point: 526.437 °C at 760 mmHg
• PKA: 9.67(at 25℃)
• Flash Point: 272.179 °C
• PSA: 81.95000
• Density: 1.19 g/cm³
• LogP: 1.02570
• Storage Temp.: Refrigerator
• Solubility.: Slightly soluble in water, freely soluble in ethanol (96 per cent), practically insoluble in acetone.
• Water Solubility.: 8.30g/L(25 oC)
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 309.19400834
• Heavy Atom Count: 22
• Complexity: 344

Purity/Quality:

99%, ^*data from raw suppliers

Nadolol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Drug Classes: Beta-Adrenergic Receptor Antagonists
• Canonical SMILES: CC(C)(C)NCC(COC1=CC=CC2=C1CC(C(C2)O)O)O
• Isomeric SMILES: CC(C)(C)NCC(COC1=CC=CC2=C1C[C@@H]([C@@H](C2)O)O)O
• Recent ClinicalTrials: Study of INV-102 Ophthalmic Solution in Adults With Moderate Symptomatic Dry Eye Disease
• Recent EU Clinical Trials: A Phase II, Randomized, Placebo-Controlled, Double-Blind, Crossover, Study of the Pharmacodynamic Effects of CST-103 co-administered with CST-107 on the Central Nervous System in Subjects with Neurodegenerative Disorders
• Recent NIPH Clinical Trials: Dose-dependent effects of green tea catechin on pharmacokinetics of nadolol in healthy volunteers
• Uses: Labeled Nadolol, intended for use as an internal standard for the quantification of Nadolol by GC- or LC-mass spectrometry. Labelled Nadolol (N201052). β-Adrenergic
• Therapeutic Function: Antiarrhythmic
• Clinical Use: Beta-adrenoceptor blocker: Hypertension Angina Arrhythmias Migraine Thyrotoxicosis
• Drug interactions: Potentially hazardous interactions with other drugs Anaesthetics: enhanced hypotensive effect. Analgesics: NSAIDs antagonise hypotensive effect. Anti-arrhythmics: increased risk of myocardial depression and bradycardia; increased risk of bradycardia, myocardial depression and AV block with amiodarone; increased risk of myocardial depression and bradycardia with flecainide. Antidepressants: enhanced hypotensive effect with MAOIs. Antihypertensives: enhanced hypotensive effect; increased risk of withdrawal hypertension with clonidine; increased risk of first dose hypotensive effect with post-synaptic alpha-blockers such as prazosin. Antimalarials: increased risk of bradycardia with mefloquine. Antipsychotics enhanced hypotensive effect with phenothiazines. Calcium-channel blockers: increased risk of bradycardia and AV block with diltiazem; hypotension and heart failure possible with nifedipine and nisoldipine; asystole, severe hypotension and heart failure with verapamil. Cytotoxics: possible increased risk of bradycardia with crizotinib. Diuretics: enhanced hypotensive effect. Fingolimod: possibly increased risk of bradycardia. Moxisylyte: possible severe postural hypotension. Sympathomimetics: severe hypertension with adrenaline and noradrenaline and possibly with dobutamine.

Technology Process of Nadolol

There total 4 articles about Nadolol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ nadolol (42200-33-9)

Guidance literature:

entspr. Naphthalin-cis-diol, Acetonitril;

Reference yield:

diacetyl nadolol → (+/-)-nadolol (42200-33-9,54933-33-4,54933-34-5,54933-35-6,54933-36-7,80844-55-9,98391-45-8)

Guidance literature:

With phosphate buffer; at 75 ℃; Rate constant; Kinetics; Thermodynamic data; ΔS<*>, E_a, pH dependence, shelf-life;

DOI:10.1002/jps.2600761215

Reference yield:

→ (+/-)-nadolol (42200-33-9,54933-33-4,54933-34-5,54933-35-6,54933-36-7,80844-55-9,98391-45-8)

Guidance literature:

Aus 2,3-cis-1,2,3,4-Tetrahydro-S-<2,3-(epoxy)propoxy>-2,3-naphthalindiol und tert.-Butylamin;

Refernces

• 1、 Condon,Cimarusti,Fox,Narayanan,Reid,Sundeen,Hauck. "Nondepressant β-adrenergic blocking agents. I Substituted 3-amino-1-(5, 6, 7, 8-tetrahydro-1-naphthoxy)-2-propanols". . p. 913 - 922. Retrieved 2007/10/06.