azelastine hydrochloride

Base Information

• Chemical Name: azelastine hydrochloride
• CAS No.: 153408-27-6
• Molecular Formula: C₂₂H₂₄ClN₃O*ClH
• Molecular Weight: 418.366
• Mol file: 153408-27-6.mol

Synonyms:1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, monohydrochloride, (S)-;(S)-Azelastine Hydrochloride;(S)-4-[(4-Chlorophenyl)Methyl]-2-(hexahydro-1-Methyl-1H-azepin-4-yl)-1(2H)-phthalazinone Hydrochloride;Azelastine Impurity;(S)-Azelastine Hydrochloride 2

Chemical Property of azelastine hydrochloride

Chemical Property:

• Melting Point: 219-221?C
• PSA: 38.13000
• LogP: 5.03740
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

(S)-AzelastineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Orally active H1-hystamine receptor antagonist. Antihistaminic.

Technology Process of azelastine hydrochloride

There total 8 articles about azelastine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

azelastine (58581-89-8,143228-85-7) → azelastine hydrochloride (79307-93-0,153408-27-6)

Guidance literature:

With hydrogenchloride; In toluene; Reflux;

Reference yield: 5.0%

→ azelastine hydrochloride (79307-93-0,153408-27-6)

Guidance literature:

Reference yield:

→ tetryzoline hydrochloride (522-48-5) + azelastine hydrochloride (79307-93-0,153408-27-6)

Guidance literature:

upstream raw materials:

1-methyl-1,2,3,5,6,7-hexahydroazepin-4-one

C₁₄H₂₁N₃O

azelastine

benzoic acid hydrazide

Downstream raw materials:

2-(1-benzylazepan-4-yl)-4-(4-chlorobenzyl)phthalazin-1(2H)-one

Refernces

• 1、 -. "Azelastine hydrochloride-containing percutaneous preparation having good percutaneous absorbability and reduced skin irritation". . . Retrieved 2008/06/13.