3-(3,5-Dihydroxy-phenyl)-propionic acid pentafluorophenyl ester

Base Information

• Chemical Name: 3-(3,5-Dihydroxy-phenyl)-propionic acid pentafluorophenyl ester
• CAS No.: 188662-00-2
• Molecular Formula: C₁₅H₉F₅O₄
• Molecular Weight: 348.226
• Mol file: 188662-00-2.mol

Synonyms:3-(3,5-Dihydroxy-phenyl)-propionic acid pentafluorophenyl ester

Chemical Property of 3-(3,5-Dihydroxy-phenyl)-propionic acid pentafluorophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-(3,5-Dihydroxy-phenyl)-propionic acid pentafluorophenyl ester

There total 3 articles about 3-(3,5-Dihydroxy-phenyl)-propionic acid pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,3,4,5,6-pentafluorophenol (771-61-9) + dihydrocaffeic acid (1078-61-1) → 3-(3,5-Dihydroxy-phenyl)-propionic acid pentafluorophenyl ester (188662-00-2)

Guidance literature:

With dicyclohexyl-carbodiimide; In 1,4-dioxane; Ambient temperature;

DOI:10.1021/jm960449w

Reference yield:

3,4-dimethoxycinnamic acid (2316-26-9) → 3-(3,5-Dihydroxy-phenyl)-propionic acid pentafluorophenyl ester (188662-00-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / H₂ / 10percent Pd/C / ethanol / 1 h / 2068.6 Torr / Ambient temperature

2: 56 percent / pyridine*HCl / 1.5 h / 180 - 200 °C

3: 95 percent / dicyclohexylcarbodiimide / dioxane / Ambient temperature

With hydrogen; pyridine hydrochloride; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; ethanol;

DOI:10.1021/jm960449w

Reference yield:

3,4-methoxycinnamic acid (2107-70-2) → 3-(3,5-Dihydroxy-phenyl)-propionic acid pentafluorophenyl ester (188662-00-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / pyridine*HCl / 1.5 h / 180 - 200 °C

2: 95 percent / dicyclohexylcarbodiimide / dioxane / Ambient temperature

With pyridine hydrochloride; dicyclohexyl-carbodiimide; In 1,4-dioxane;

DOI:10.1021/jm960449w

upstream raw materials:

2,3,4,5,6-pentafluorophenol

dihydrocaffeic acid

3,4-dimethoxycinnamic acid

3,4-methoxycinnamic acid

Downstream raw materials:

N-[2-(3,5-Bis-benzyloxy-phenyl)-ethyl]-3-(3,5-dihydroxy-phenyl)-propionamide

Refernces