4-(1-ADAMANTYL)-2-NITROPHENOL

Base Information

• Chemical Name: 4-(1-ADAMANTYL)-2-NITROPHENOL
• CAS No.: 32599-84-1
• Molecular Formula: C₁₆H₁₉NO₃
• Molecular Weight: 273.332
• Mol file: 32599-84-1.mol

Synonyms:4-(adamantan-1-yl)-2-nitrophenol

Chemical Property of 4-(1-ADAMANTYL)-2-NITROPHENOL

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

4-(1-Adamantyl)-2-nitrophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1-ADAMANTYL)-2-NITROPHENOL

There total 3 articles about 4-(1-ADAMANTYL)-2-NITROPHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-adamantylphenol (29799-07-3) → 4-(adamantan-1-yl)-2-nitrophenol (32599-84-1)

Guidance literature:

With nitric acid; acetic acid; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/acs.organomet.9b00533

Reference yield:

phenol (108-95-2,27073-41-2) → 4-(adamantan-1-yl)-2-nitrophenol (32599-84-1)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / 6 h / 20 °C / Inert atmosphere

2: nitric acid; acetic acid / 0.5 h / 20 °C / Inert atmosphere

With nitric acid; acetic acid; trifluoroacetic acid;

DOI:10.1021/acs.organomet.9b00533

Reference yield:

1-adamanthanol (768-95-6) → 4-(adamantan-1-yl)-2-nitrophenol (32599-84-1)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / 6 h / 20 °C / Inert atmosphere

2: nitric acid; acetic acid / 0.5 h / 20 °C / Inert atmosphere

With nitric acid; acetic acid; trifluoroacetic acid;

DOI:10.1021/acs.organomet.9b00533

upstream raw materials:

4-adamantylphenol

phenol

1-adamanthanol

Refernces

• 1、 Xia, Yan,Duan, Qiong,Zhao, Bao-Hua,Li, Dong-Feng,Hou, Rui-Bin. "Design, synthesis and structure-activity relationship studies of novel 4 (1-adamantyl) phenyl analogues as hif-1α inhibitors". . p. 338 - 346. Retrieved 2016/07/06.
• 2、 Osyanin, Vitaly A.,Ivleva, Elena A.,Klimochkin, Yuri N.. "Facile approach for the synthesis of 2,3,4,9-tetrahydro-1H-xanthen-1-ones and 8,9,10,12-tetrahydro-11H-benzo[a]xanthen-11-ones via trapping of o-quinone methides". experimental part. p. 1832 - 1847. Retrieved 2012/04/23.