7,8-DIDEHYDRO-4,5-α-EPOXY-14-HYDROXY-3-METHOXY-17-METHYLMORPHINAN-6-ONE-N-OXIDE

Base Information

• Chemical Name: 7,8-DIDEHYDRO-4,5-α-EPOXY-14-HYDROXY-3-METHOXY-17-METHYLMORPHINAN-6-ONE-N-OXIDE
• CAS No.: 19763-77-0
• Molecular Formula: C18H21NO5
• Molecular Weight: 329.353
• Mol file: 19763-77-0.mol

Synonyms:

Chemical Property of 7,8-DIDEHYDRO-4,5-α-EPOXY-14-HYDROXY-3-METHOXY-17-METHYLMORPHINAN-6-ONE-N-OXIDE

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7,8-DIDEHYDRO-4,5-α-EPOXY-14-HYDROXY-3-METHOXY-17-METHYLMORPHINAN-6-ONE-N-OXIDE

There total 2 articles about 7,8-DIDEHYDRO-4,5-α-EPOXY-14-HYDROXY-3-METHOXY-17-METHYLMORPHINAN-6-ONE-N-OXIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.7%

thebaine (115-37-7) → 14β-hydroxycodeinone N-oxide (19763-77-0) + 14-hydroxycodeinone (508-54-3)

Guidance literature:

With formic acid; sulfuric acid; dihydrogen peroxide; at 35 - 40 ℃; for 20h; Yields of byproduct given;

DOI:10.1002/ardp.19963290608

Reference yield:

thebaine (115-37-7) → 14β-hydroxycodeinone N-oxide (19763-77-0) + 14-hydroxycodeinone (508-54-3) + 8β,14-dihydroxy-7,8-dihydrocodeinone (23185-97-9) + trans-10-hydroxythebaine

Guidance literature:

With formic acid; sulfuric acid; dihydrogen peroxide;

DOI:10.1002/(SICI)1521-4184(199910)332:10<369::AID-ARDP369>3.0.CO;2-5

Reference yield:

14β-hydroxycodeinone N-oxide (19763-77-0) → Oxycodone (76-42-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; for 2.5h; under 1551.4 Torr; Yield given;

DOI:10.1002/ardp.19963290608

upstream raw materials:

thebaine

Downstream raw materials:

Oxycodone

Refernces

• 1、 -. "PRODUCTION OF 6-HYDROXY MORPHINANS WITHOUT THE ISOLATION OF INTERMEDIATES". Paragraph 0130. . Retrieved 2015/05/13.