3-(2-Naphthyl)phenol

Base Information

• Chemical Name: 3-(2-Naphthyl)phenol
• CAS No.: 33104-32-4
• Molecular Formula: C₁₆H₁₂O
• Molecular Weight: 220.271
• ChEMBL ID: CHEMBL258687
• DSSTox Substance ID: DTXSID90487649
• Nikkaji Number: J392.701F
• Mol file: 33104-32-4.mol

Synonyms:3-(2-naphthyl)phenol;2-(3-Hydroxyphenyl)naphthalene;33104-32-4;3-(NAPHTHALEN-2-YL)PHENOL;3-naphthalen-2-ylphenol;CHEMBL258687;3-Naphthalene-2-ylphenol;3-naphthalen-2-yl-phenol;SCHEMBL3015094;DTXSID90487649;FQDQJXSIUCYJDC-UHFFFAOYSA-N;BDBM50373033;MFCD18312885;AKOS017557816;PD119519;Z3236271560

Chemical Property of 3-(2-Naphthyl)phenol

Chemical Property:

• XLogP3: 4.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 220.088815002
• Heavy Atom Count: 17
• Complexity: 250

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C=C(C=CC2=C1)C3=CC(=CC=C3)O

Technology Process of 3-(2-Naphthyl)phenol

There total 11 articles about 3-(2-Naphthyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-(naphthalen-2-yl)cyclohex-2-en-1-one (42160-93-0) → β-(3-hydroxyphenyl)naphthalene (33104-32-4)

Guidance literature:

With hydrogen bromide; oxygen; copper(ll) bromide; In 1,4-dioxane; water; at 20 ℃; for 20h; Sealed tube;

DOI:10.1039/c3ra43071e

Reference yield: 99.0%

3-Bromophenol (591-20-8) + naphthalene-2-boronic acid (32316-92-0) → β-(3-hydroxyphenyl)naphthalene (33104-32-4)

Guidance literature:

With lithium hydroxide monohydrate; C₂₉H₄₀N₂O₃Pd; In water; N,N-dimethyl-formamide; at 50 ℃; for 24h;

DOI:10.1002/aoc.3778

Reference yield: 98.0%

β-(3-methoxyphenyl)naphthalene (33104-31-3) → β-(3-hydroxyphenyl)naphthalene (33104-32-4)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1021/ol0701621

upstream raw materials:

1-(2-oxopropyl)pyridinium chloride

3-diethylamino-1-[2]naphthyl-propan-1-one; hydrochloride

β-(3-methoxyphenyl)naphthalene

2-bromonaphthalene

Downstream raw materials:

5-naphthalen-2-yl-2,2-diphenyl-2H-chromene

7-naphthalen-2-yl-2,2-diphenyl-2H-chromene

Refernces

• 1、 -. "COMPOUNDS AND METHODS FOR TREATING OXALATE-RELATED DISEASES". Paragraph 0248; 0280-0281. . Retrieved 2019/09/12.
• 2、 Gao, Hongyin,Zhou, Zhe,Kwon, Doo-Hyun,Coombs, James,Jones, Steven,Behnke, Nicole Erin,Ess, Daniel H.,Kürti, László. "Rapid heteroatom transfer to arylmetals utilizing multifunctional reagent scaffolds". . p. 681 - 688. Retrieved 2017/06/30.